Health
A Covid brain study by Georgia State University points out that the nose is important
This study, conducted in mice, may have implications for understanding the case of humans exhibiting neurological symptoms with COVID.
Atlanta — New COVID-19 study According to Georgia State University, the coronavirus can stay in the brain longer than the lungs and can affect the infection longer, even after it has been removed from the lungs.
that is Not necessarily unique For COVID, this study may affect how some humans exhibited the following neurological symptoms: Lose taste and smellIt lasts a long time in the so-called “long distance”. And why can an individual’s condition seem to begin to improve but worsen?
Research Published in the January issue Of the journal Virus, We then investigated how 20 mice infected with SARS-CoV-2 via the nasal cavity were affected.
In the lungs of mice, cytokine and chemokine levels began to decline, rising in 3 days, after which most began to disappear.
Cytokines and chemokines indicate the strength of the body’s cellular response to the virus. Higher levels indicate that the virus has a greater impact on the system and therefore a more active cellular response.
But at the same time, in the brain, levels of these cytokines and chemokines were almost negligible during the first few days and by day 5 had spiked to much higher levels than previously observed in the lungs. By day 6, all mice had died.
“These results show that the inflammatory response was more pronounced in the brain than in the lungs in late infection,” the study said. “The development of serious disease in SARS-CoV-2 infected mice was associated with peak viral levels in the brain, immune cell infiltration, and (central nervous system) cell death.”
“That’s why we see severe illness and all these multiple symptoms, like all these long-haul carriers with heart disease, stroke, and loss of smell and taste,” said Georgia State University. Associate Professor Mukeshkumar, Principal Investigator of Research, Told on the school website.. “It’s all about the brain, not the lungs.”
The rise of the virus in the brain as it falls into the lungs may partially explain why some patients showed improvement with only sudden exacerbations and death.
The role of the nose as a direct passage also seems to play a role, suggesting that the infection may make a difference whether it is inhaled through the nasal passages or into the lungs.
This study found that SARS-CoV-2 can infect cells within. Concha, The nasal passage that purifies the incoming air, and the olfactory bulb, which is basically the part of the brain near the anterior that produces the sensation of smell. Infections there can lead to a wider range of brain infections.
“Viral infections of cells in these tissues of humans may explain the loss of olfaction associated with some COVID-19 cases,” the study said. “Detection of viral replication in these tissues allows SARS-CoV-2 to access the brain by first infecting the olfactory bulb and then spreading to the brain by infecting the connecting brain neuronal axons. I suggest. “
“Our idea of having a respiratory illness is not always true,” Kumar said.
“When the brain infects the brain, it can affect anything because it controls your lungs, your heart, everything,” he says. Told the Georgia website.. “The brain is a very sensitive organ. It’s all central processing units.”
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