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Researchers Test New Combination Therapy for Head and Neck Cancer | Health News
Washington: Researchers at the University of Cincinnati have tested new combination therapies in animal models to see if they can already find ways to further improve effective treatments. This can help humans sooner or later, as they use drugs approved by the Food and Drug Administration to do that.
The results of these findings are published in the journal Cancer Letters. We hope that Vinita Takiar, MD, and PhD lab postdocs Christina Wicker, PhD will lead the study and one day extend the lifespan of patients. “Head and neck cancer, like any other cancer, is truly life-changing,” she says.
“Head and neck cancer can affect the throat, tongue, or nose, and patients often cannot swallow, talk, or eat. It is some of the most social and enjoyable parts of life. I really take it away. “
The researchers in this study combined radiation therapy with a drug that stops key enzymes in the cell pathways that change in cancer cells and causes them to grow rapidly to resist treatment (teragrenastat). According to Wicker, the drug has already been studied in multiple clinical trials to see if it can improve the treatment of various cancers.
“To date, no one has investigated whether this drug may improve radiation therapy for head and neck cancer. Most importantly, the compounds in this drug are patient-tolerant. It’s high and has minimal side effects, “she says.
Using animal models, researchers found that only drugs reduce head and neck growth. cancer The cells were up to 90%, and the effectiveness of radiation in animals with head and neck tumors was also increased by 40%. “These results, especially in previous clinical trials that showed that the drug was well tolerated in patients, could move even faster to clinical trials for head and neck cancer,” Wicker said. I will.
“I hope that in the future this drug will be used to make radiation therapy for head and neck cancer more effective.” Currently, the most common treatment for that cancer is radiation therapy. The cancer eventually recurs in up to half of the patients and often does not respond positively to the second treatment. [traditional] The drug is less effective, it becomes harder to control the growth of the cancer, and the cancer can spread rapidly to other organs, “she says. “It is very important for scientists and clinicians to develop new cancer treatments to improve the treatment of this type of cancer, and hopefully our findings are another way to help patients. Will provide a choice. “
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