Health
Immunotherapy may be more beneficial in the treatment of small cell lung cancer
According to data presented at the 2020 World Congress on Lung Cancer, immuno-tumor therapy provided significant potential health benefits for patients with small cell lung cancer, but younger patients appeared to respond best to treatment.
“The methods of this study and the inferences obtained from this study are based on a range of clinically plausible protocols for clinicians in assessing and quantifying the expected survival benefits of (immuno-oncology) therapy. And is positioned to help decision makers. Jason Gordon, Honorary Associate Professor at Nottingham University in the United Kingdom, said in a virtual presentation of the data.
Previously, immuno-oncology has been successful in improving the overall survival (OS) response of small cell lung cancer.
The purpose of this comparative approach study was to find past age-specific small cell lung cancer survival rates in the United States and use mixed sclerosis modeling to compare these with expected immuno-oncological survival rates. According to Gordon, a mixture of patient survival outcome distributions.
To find past OS in patients with metastatic small cell lung cancer (baseline age, 70 years), the authors of the study found a Surveillance Epidemiology and End Results (SEER) database associated with a median expected OS of 5.8 months. I used the information from. Of the patients in this database, about 11% survived at 26 months and about 5% survived at 60 months.
Data from the CheckMate 032 trial were also used to assess the efficacy of Opdivo (nivolumab), with a median OS of 4.4 months. About 21% of the patients in this study survived at 26 months. Using this study, they assumed the expected results after 26 months and predicted that 10% of the eligible population would achieve a lasting response.
Incremental survival was estimated at the population level by comparing historical results from SEER with estimates of long-term survival in patients who received immuno-oncology therapy.
“Our results show that there were significant and consistent survival benefits associated with treatment (related to immuno-oncology) compared to past standard treatments,” Gordon said. I will.
Patients treated with immuno-oncology had an estimated mean OS of 29.5 months and increased survival by 21.2 months. More were observed in younger patients compared to older patients, but there was a significant increase in survival across all ages.
Researchers used a plausible long-term response fraction for 10% to 100% of survivors (about 21% of the study population) at 26 months. This represents 2.1% to 21% of all patients. Applying age-adjusted incremental survival estimates to a population with small cell lung cancer (13,570 patients) resulted in approximately 27,000 lifespans with a 10% long-term response rate and 10,138 lifespans with a 2.1% long-term response rate. I did. Response rate and 43,476 lifespan obtained with a long-term response rate of 21%.
“We need to consider future studies investigating additional datasets, populations, and the generalized ability of research reasoning,” Gordon concludes.
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