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New Mutations Can Make Current Vaccine Research “Fillet”: Research

 


Key Point

  • Taiwanese and Australian team of researchers discover evidence of new coronavirus mutations
  • May affect current vaccine development
  • However, other experts have not yet peer reviewed the findings.

As scientists are competing to develop a vaccine for COVID-19, new research has identified an important new coronavirus mutation that may make current vaccine development “futil”.

Researchers at National Changhua University of Education in Taiwan and Murdoch University in Australia said the new coronavirus mutations showed changes in spike proteins that allow the virus to bind to an enzyme found in the lungs.

Scientists have been studying this receptor and looking for suitable antibodies to counter its effects. But unexpected structural changes “warn that ongoing vaccine development could be futile in future epidemics if mutations were more identified,” experts said. biorxiv.org.

Vaccine-4946480_960_720 Scientists around the world are competing for new vaccines against the new coronavirus and COVID-19. Photo: Pixabay

Experts discovered a new coronavirus mutation in an Indian patient sampled in early January. The patient is a medical student who went to Wuhan, but the strain did not resemble any Chinese subspecies.

The research team released the entire genome sequence for this sample in March. However, experts have also confirmed that the new coronavirus mutation rate is slow.

“We confirmed that the mutation rate of SARS-CoV-2 was relatively low, but also demonstrated that new mutations with different pathogenic and immunological properties have already emerged.” The above.

This study has not been peer reviewed. Therefore, the team’s findings may still be denied by other experts.

Benjamin Neumann of the Texas A & M University Biological Sciences, which is not part of the study, said viral mutations, like the influenza virus vaccine, may need to be regularly tested and updated.

“Although the influenza virus is constantly mutating and changing at about the same rate as the coronavirus, we can successfully vaccinate this moving target,” Neumann said.

Immunology instructor Jenna Macchochi, who works at the University of Sussex, also said current vaccine development is not necessarily affected by the mutations found.

“Any mutation would be expected to be a small mutation,” Macchochi said. “The mutations that emerged in this report appear to reduce binding to ACE2, implying reduced toxicity that could mean reduced infectivity.”

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