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The “most concerned” coronavirus mutation occurred spontaneously in a British variant




London (Reuters)-Outbreaks that are part of a committee advising the UK government that “most concerned” coronavirus mutations that could affect vaccine efficacy have occurred spontaneously in UK variants. A professor of medicine said on Tuesday.

The E484K mutation that occurs in viral peplomer is the same change seen in South African and Brazilian variants that raise international concerns.

Studies in several laboratories have shown that vaccines and antibody therapies are less effective against South African variants.

In contrast, early evidence showed that the vaccine works equally well against a British variant called B.1.1.7 that originally did not have the E484K mutation.

“The most feared mutation we call E484K also occurred spontaneously in some new Kent strains in the country,” Calum Semple, a member of the Emergency Science Advisory Group, said on BBC radio. .. Southern English County, where the British variant was first detected.

Concerns over South African variants have led UK authorities to launch a door-to-door mass trial of 80,000 people living in areas unrelated to South Africa where cases of the variants were found.

The fact that the E484K mutation occurred spontaneously in the United Kingdom was already reported in a technical briefing issued by the British Public Health Service, but it was not widely noticed outside the scientific community.

The report states that mutations were detected in 11 B.1.1.7 genomes, probably as a result of “multiple acquisition events”, and not all 11 genomes are linked to each other, but mutations. But in different places.

The name E484K is, in layman’s terms, like the coordinates of a map. The number 484 is the exact location of the mutation, the letter E is the amino acid it originally originated from, and the letter K is the amino acid it was mutated.

Julian Tan, a virologist at the University of Leicester, said: “Unfortunately, the UK cannot manage these various variants, so this population could become a crucible for various emerging SARS-COV-2 / COVID-19 variants.

Reported by Estelle Shirbon and Alistair Smout.Edited by Nick McPhee and Gareth Jones


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