Health
Researchers have found new clues about how SARS-CoV-2 can infect cells
The molecular details of how SARS-CoV-2 enters and infects cells are not yet clear. Researchers at Uppsala University tested bioinformatics predictions made by another research group and identified receptors that could be important players in the process.Results will be published in the journal Scientific signaling And at the AAAS Annual Meeting this week.
The SARS-CoV-2 spike protein binds to the protein ACE2, which is located outside human cells. This triggers a series of events that lead to the invasion of cells by the virus. The molecular details of this process remain ambiguous despite numerous studies on SARS-CoV-2 and other coronaviruses. In addition, ACE2 is absent in human lung cells. This suggests that different players are involved when the virus infects these cells.
Recent research by researchers at Uppsala University sheds some new light on this issue. The study was published in succession to a study by an international team led by Dr. Toby Gibson of the European Molecular Biology Laboratory (EMBL) in Heidelberg. Gibson’s research predicted potential interactions that could be important for Sars-CoV-2 to enter cells.
Researchers at Uppsala University test biometric predictions in vitro, and ACE2 and the potential co-receptor integrin beta 3 are involved in endocytosis and autophagy (the cellular process of substance uptake and disposal). We were able to show that we interact with important players. This means that these processes can be hijacked by the virus during infection.
The Gibson team is a world leader in bioinformatics analysis of these types of interactions, and we were excited to follow up on their predictions. Our results also helped them improve their analysis. Participating in this project was an easy decision as our laboratory has a keen interest in host-pathogen protein-protein interactions. “
Ylva Ivarsson, Professor, Uppsala University
Source:
Journal reference:
Kliche, J. , et al. (2021) The cytoplasmic short chain motif of ACE2 and integrin β3 links SARS-CoV-2 host cell receptors to mediators of endocytosis and autophagy. Scientific signaling. doi.org/10.1126/scisignal.abf1117..
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