Health
“Game Changer” Obesity Drugs Reduce Weight By 20%
Studies have shown that “game changer” drugs for treating obesity can reduce weight by up to 20 percent.
In a global trial involving thousands of international participants, UCL scientists found that more than one-third of participants taking the drug lost more than one-fifth of their total body weight. discovered.
Researchers welcome this discovery as a potential step in improving the health of people living with obesity.
They said that what was previously only possible with weight loss surgery can only be achieved with drugs.
The drug, semaglutide, works by taking over the body’s own appetite-regulating system in the brain, reducing hunger and calorie intake.
Rachel Butterham, a professor of obesity, diabetes and endocrinology who heads the UCL Obesity Research Center and UCLH Weight Management Center, is one of the leading authors of this paper, which was attended by approximately 2,000 people in 16 countries.
Professor Butterham said: “The results of this study represent significant progress in improving the health of obese people.
“Three-quarters of people who received semaglutide 2.4 mg lost more than 10% of their body weight, and more than one-third lost more than 20%.
“No other drug is approaching producing this level of weight loss-it’s really a game changer.
“For the first time, people can achieve through drugs what was possible only through weight loss surgery.”
She added that the drug could have a significant impact on UK health policy over the next few years.
According to a study published in the New England Journal of Medicine, the average number of participants in the study lost 15.3 kg.
It has been reported to improve overall quality of life, with a reduction in risk factors for heart disease and diabetes such as waist circumference, blood fat, blood sugar and blood pressure.
Professor John Wilding of the University of Liverpool, UK Principal Investigator for the study, added: “This is an important advance in the treatment of obesity.
“Semaglutide is already approved and is clinically used at low doses for the treatment of diabetes, so doctors are already familiar with its use.”
Based on evidence from this study, semaglutide was submitted to the National Institute of Clinical Excellence (NICE), the European Medicines Agency (EMA), and the US Food and Drug Administration (FDA) for regulatory approval as a treatment for obesity. it was done.
The study enrolled 1,961 overweight or obese adults and was conducted in 129 locations in 16 countries in Asia, Europe, North America and South America.
Participants took 2.4 mg of semaglutide or the corresponding placebo weekly by subcutaneous injection
Overall, 94.3% of participants completed the 68-week survey that began in the fall of 2018.
Participants also received individual face-to-face or telephone counseling sessions from registered dietitians every four weeks to comply with low-calorie diets and increased physical activity, and to provide guidance, behavioral strategies, and motivation.
In addition, participants received incentives such as kettlebells and food scales to mark progress and milestones.
People taking semaglutide lost an average of 15.3 kg and had a BMI of minus 5.54.
In the placebo group, an average weight loss of 2.6 kg was seen and BMI decreased by -0.92.
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