Health
Roche’s tocilizumab reduces mortality in hospitalized COVID-19 patients-study
London (Reuters)-Roche’s arthritis treatment tocilizumab reduced the risk of death in patients hospitalized with severe COVID-19, reduced recovery time, and reduced the need for mechanical ventilation, shown Thursday. Results of large-scale testing.
The results of the RECOVERY trial, which has been testing various potential treatments for COVID-19 since March 2020, show whether tocilizumab has any benefit to COVID-19 patients after a number of recent mixed trial results. Should help eliminate confusion about.
Peter Horby, a professor of emerging infectious diseases at Oxford University and co-principal investigator in recovery trials, said: “The benefits of tocilizumab have been shown to extend to all COVID patients with severe inflammation at low oxygen levels.
A RECOVERY trial last June found that the cheap and widely available steroid dexamethasone reduced mortality in the most severe COVID-19 patients by about one-third. The drug has since rapidly become part of the recommended standard of care for critically ill patients.
Tocilizumab, sold under the brand name Actemra, is an intravenous anti-inflammatory monoclonal antibody drug used to treat rheumatoid arthritis. It was added to the study in April 2020 in patients with COVID-19 who require oxygen and have evidence of inflammation.
Study data were from 2,022 patients with COVID-19 randomly assigned to receive tocilizumab by intravenous infusion and compared to 2,094 patients randomly assigned to routine care only. It was. Researchers said that 82% of all patients are taking systemic steroids such as dexamethasone.
The results showed that treatment with tocilizumab significantly reduced mortality-596 (29%) of patients in the tocilizumab group had 28 days compared to 694 (33%) of patients in the regular care group. Died within.
This corresponds to an absolute difference of 4%, which means that one additional life is saved for every 25 patients treated with tocilizumab, Horby and his co-principal researcher Martin Landray said. It was.
They added that the benefits of tocilizumab were clearly seen in addition to the benefits of steroids.
“When used in combination, the impact is significant,” said Landray, a professor of medicine and epidemiology at Oxford University.
He clearly demonstrates the worst consequences of COVID-19: tocilizumab and dexamethasone in addressing improved survival, shorter hospital stays, and reduced ventilator needs. I added.
Bill Anderson, head of pharmaceuticals at Roche, said last week that previous mixed results differed in the type of patients studied, when they were treated, and endpoints (the turning points where success or failure is measured). He said it was likely due to.
“I think we’re zooming in on both the most relevant endpoints and the relevant patient population,” Anderson said. “The ideal candidate seems to be a patient in the acute phase of an inflammatory attack.”
Actemra, along with Kevzara, a similar drug from Sanofi, showed that preliminary data from a small study called REMAP-CAP could reduce hospital stays by about 10 days, after which patients with COVID-19 in the intensive care unit It was approved by NHS in the UK in early January.
In 2020, Actemra became Roche’s fifth-selling drug, surpassing $ 3 billion and nearly $ 600 million with COVID-19 treatment.
A report by Kate Keland in London and an additional report by John Miller in Zurich. Edited by David Evans
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