A simple urine test can detect uterine cancer

A proof-of-concept study by scientists at the University of Manchester and the University of Manchester NHS Foundation Trust (MFT) allows simple non-invasive tests to accurately detect uterine cancer.

The· Non-invasive testDetects cancer By observing a urine or vaginal sample under a microscope, it can be of great benefit to the patient if adopted throughout the NHS.

Women are now diagnosed using a narrow telescope called a hysteroscope to examine the inside of the uterus where a biopsy is performed.

However, 31% of women who receive this procedure have to repeat this procedure due to technical difficulties and intolerable pain.

And thousands of women who don’t have Uterine cancer It also goes through procedures that have a significant economic impact on the NHS.

Research team publishing the analysis Nature CommunicationsWe believe that if large-scale trials are conducted, new detection tools (samples that women can collect at home) can be incorporated into clinical practice.

A team led by Professor Emma Crosbie of the University of Manchester tested the new tool on 103 women with known cancers and 113 women with unexplained postmenopausal bleeding.

The percentage of women with uterine cancer identified with the new tool was 91.7%. The percentage of women without uterine cancer who tested negative with the new tool was 88.9%.

“Our results show that uterine cancer cells can be detected in urine and vaginal samples using a microscope,” said an honorary consultant in gynecologic oncology at St. Mary’s Hospital, part of the MFT. One Professor Crosby said.

“Woman test If the test is positive, you can refer to the diagnostic test, and if it is negative, you can rest assured that you do not need costly procedures that are unpleasant, invasive, and induce anxiety.

“We believe our new test will provide a simple, acceptable and manageable solution that can be used in primary care as a triage tool for women with suspected cervical cancer.”

Uterine cancer is the sixth most common cancer affecting women, with approximately 382,000 new diagnoses and 89,900 deaths worldwide in 2018.

Most women appear early after the onset of postmenopausal bleeding and have a good prognosis.

However, 20% of women have progressive disease and the 5-year survival rate is only 15%.

Professor Crosby said: “There is an urgent need for new strategies to facilitate early diagnosis of uterine cancer to enable curative hysterectomy in women with biologically invasive disease.

“But postmenopausal bleeding is a recognizable symptom, but only 5-10% of women suffering from it have an ominous underlying medical condition. Therefore, when this test is adopted, these patients I feel at ease. “

“Our result is Uterus Cancer cells can be detected in urine and vaginal samples using a microscope. Women who test positive on this test may be referred to a diagnostic study, and women who test negative are uncomfortable, invasive, anxious, and safe and secure without the need for costly procedures. “Masu,” said Professor Emma Crosby.

Uterine cancer is known to shed malignant cells from the cervix to the lower genital tract. These cells can be collected from the vagina by gentle irrigation or from self-collected urine samples.

Testing for cells, known as cytology, can be a useful tool because the expertise and infrastructure needed to donate cells have already been established in the NHS.

Its benefits include low cost, fast turnaround time, and point-of-care diagnostic potential.

She added: “Our data are very promising, but we need to confirm them in larger diagnostic accuracy studies. Woman Postmenstrual bleeding of unknown cause is undergoing regular diagnostic investigations. “

This study was supported by the National Institute for Health Research (NIHR) Center for Biomedical Research.

The diagnostic accuracy of cytology to detect endometrial cancer in urine and vaginal samples Nature Communications