New Prostate Cancer Test Can Avoid Unnecessary Biopsy

A validation study of more than 1,500 patients found that urinalysis based on a study at the University of Michigan Rogel Cancer Center was able to avoid one-third of unnecessary prostate cancer biopsies, but only a few. It is possible that only the patient could be detected. The survey results are published in the March issue of. Urology Journal..

The My Prostate Score test, commercialized by UM startup Lynx DX, measures the level of cancer-specific genes in a patient’s urine. This is in a UM study that found that half of all prostate tumors had a specific genetic abnormality in which the TMPRSS2 and ERG genes were rearranged and fused on the chromosome to switch on. Is based. Prostate cancer development of.

Currently, one of the best doctors’ ways to detect prostate cancer is Blood test For prostate-specific antigens, commonly known as the PSA test. Elevated PSA levels may indicate cancer, but the majority of men with elevated PSA do not actually have prostate cancer.

Men with elevated PSA tests to determine which patients have or do not have cancer Invasive treatment It is called a transrectal biopsy. Prostate biopsy is unpleasant for the patient and the risk of complications is small. MRI scans are also used to detect prostate cancer, but they can miss cancerous lesions, with much higher cost and limited availability.

“Our ultimate goal is whether the MyProstateScore test can be a practical and reliable test that can eliminate the need for more costly and invasive tests for men referred to prostate biopsy. “It was to determine,” said MPH, MD, MD, lead author of the study. Clinical instructor of urology in Michigan medicine.

Tosoian and his two co-authors are the founders of LynxDX and hold shares in the company.

Not all prostate cancers are equally worrisome. Many occur later in life and grow very slowly, so the best thing to do is simply monitor them. According to researchers, it is these slow-growing cancers or cancers that, despite rising PSA levels, can be spared from more invasive and costly procedures if doctors get better tests. It is a patient without.

Validating studies included patients found at academic health centers and community health facilities. Of these 1,525 patients, 338 (22%) detected group grade 2 or higher cancer on biopsy. This means that the cancer is so serious that it requires immediate treatment.

387 biopsies that did not find cancer or slow-growing ones if the MyProstateScore test was available to patients in the study cancer The study found that it could have been avoided. In the meantime, the test would have missed only 10 clinically significant cancers that would justify immediate treatment.

“The data show that this simple secondary testing approach can reduce the use of more costly and invasive procedures after PSA testing,” says Tosoian.

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Researchers published spermine risk scores for the diagnosis of prostate cancer

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For more information:
Jeffrey J. Tosoian et al, Using the MyProstateScore Test to Exclude Clinically Significant Cancers: Verification of a Simple Clinical Testing Approach, Urology Journal (2020). DOI: 10.1097 / ju.0000000000001430

Provided by
University of Michigan

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