Health
Here’s how the coronavirus hijacks human cells:
the scientistIncluding one of Indian origin, has identified some of the human proteins that the new coronavirus can use to hijack host cell processes. This is an advance that may lead to the development of new drugs to treat COVID-19.
Researchers, including Manjeet Kumar of the European Molecular Biology Laboratory (EMBL) in Germany, have analyzed the chains of amino acid molecules that make up human proteins involved in coronavirus infection, including a class of proteins called integrin.
In previous studies, the SARS-CoV-2 virus that causes COVID-19 can enter cells through a process called endocytosis when it binds to the cell surface receptor ACE2 and other proteins such as integrins. I already know.
In a current study published in the journal Science Signalling, scientists have specifically focused on short strings of amino acids called short chain motifs (SLiMs) that are involved in transmitting information between the inside and outside of cells. ..
They found that some integrins contained SLiM, which is likely to be involved in the cellular process of uptake and disposal of substances called endocytosis and autophagy.
“If SARS-CoV-2 targets proteins involved in endocytosis and autophagy, it means that these processes can be hijacked by the virus during infection,” the EMBL study said. Co-author Balint Meszaros said.
Researchers believe that this finding may lead to new therapeutic approaches for COVID-19.
“SLiM can be” switched “to turn virus intrusion signals on or off. This means that if we can find a way to undo these changes using drugs, we may prevent the coronavirus from invading cells. “
“Together, these discoveries could identify a potential link between autophagy and integrin signaling and lead to new ways to prevent viral infections,” scientists write in a study.
Based on the results, researchers have compiled a list of existing drugs that prevent endocytosis and autophagy.
“If clinical trials prove that some of these drugs work against COVID-19, this could be a game changer,” Kumar added.
This story was published from the Wire Agency Feed without changing the text. Only the heading has changed.
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