Health
Potential drugs can effectively treat deadly childhood brain tumors
Childhood brain tumors develop in the child’s brain or similar tissues and structures. Abnormal growth of cells in the brain causes brain tumors in children. After that, a malignant childhood brain tumor becomes a brain tumor.
About 20 Australian children report to die each year from diffuse intrinsic bridge glioma (DIPG), an incurable brain tumor. The average age of DIPG diagnosis is only 7 years. There is no effective cure, and almost all children die of the disease, usually within a year of diagnosis.
But don’t worry.New research reveals that inhibition of key enzymes that control large networks of proteins important for cell division and growth leads to a new class of drugs that can stop the deadly brain. I made it cancer From growth.
The study, published in Nature Communications, showed that chemical inhibition of the enzyme PRMT5 could suppress the growth of glioblastoma cells.
Cellular senescence can also suppress brain tumors
Inhibition of PRMT5 caused cellular senescence, similar to what happens to cells during aging when they lose the ability to divide and grow. Cellular senescence is also a powerful tumor suppressor mechanism that prevents the relentless division of cancer cells.
“By inhibiting one protein, PRMT5, we were able to influence the cascade of proteins involved in cell division and growth,” said Cheryl Arrowsmith, a researcher at the University of Toronto.
“The traditional way to stop cell division was to block one protein, which provides new assumptions for the future development of new, more accurate treatments,” Arrowsmith added. I did.
In this study, the team tested a group of new small molecules designed to specifically inhibit key cellular enzymes under development, including one that arrests glioblastoma brain growth. I checked if it was. tumor Laboratory cells.
Brain Tumor-This is What You Need to Know
Brain tumor cells were isolated from the patient’s tumor and grown in the laboratory in a way that preserved the unique properties of cancer stem cells.
They found that certain molecules (precursors of real therapeutic agents) inhibit the same enzyme, PRMT5, and stop the growth of most cancer stem cells from these patients.
However, they also warn that the actual treatment of patients is years away and requires the development and testing of clinically relevant and safe versions of PRMT5 inhibitors that can access the brain.
Tumor cell molecular signature
The researchers also examined the molecular characteristics of patient-derived glioblastoma cells by comparing well-reacted and unreacted cells.
They discovered different molecular signatures of the tumor cells that reacted. In the future, this may lead to specific tumor biomarkers and may help identify patients who respond best to this new class of drugs.
Release date: February 15, 2021 10:56 am
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