Connect with us

Health

Studies reveal how longevity genes protect brain stem cells from stress

Avatar

Published

on


Studies reveal how longevity genes protect brain stem cells from stress

Antioxidant therapy promotes the birth of new neurons from stem cells by suppressing stress signaling. Credit: Paik Lab.

Genes associated with abnormally long lifespan in humans protect brain stem cells from the harmful effects of stress, according to a new study by researchers at Weil Cornell Medicine.

Studies of humans living for over 100 years have shown that many share a rare version of a gene called the forkheadbox protein O3 (FOXO3). With that discovery, Dr. Jihye Paik, an associate professor of pathology and laboratory medicine at Weill Cornell Medicine, and her colleagues investigated how this gene contributes to brain health during aging.

In 2018, Dr. Pike and her team showed that mice lacking the FOXO3 gene in the brain could not cope with stress conditions in the brain, leading to progressive death in the brain. ..Their new study was published on January 28th Nature CommunicationsReveals that FOXO3 maintains the ability of the brain to regenerate by preventing From division to the environment supporting the survival of new cells.

“Stem cells produce new brain cells, which are essential for our learning and memory as a whole. “When stem cells divide uncontrolled, they are depleted. The FOXO3 gene appears to play its role by stopping stem cell division,” said Dr. Pike, a member of the Sandra and Edward Meyer Cancer Center at Weil Cornell Medicine. is. It has passed. “

Many challenges, such as inflammation, radiation, and lack of proper nutrients, can stress the brain.However, Dr. Pike and her colleagues specifically investigated what happens when brain stem cells are exposed. It occurs when harmful types of oxygen accumulate in the body.

“I learned that the FOXO3 protein is directly modified by oxidative stress,” she said.This modification sends the protein to the nucleus of the stem cell, where it turns on the stress response. ..

The resulting stress response leads to the depletion of a nutrient called s-adenosylmethionine (SAM). This nutrient is needed to help a protein called lamin form a protective envelope around the DNA in the stem cell’s nucleus.

“Without SAM, Lamin would not be able to form this strong barrier and DNA would begin to leak,” she said.

Cells mistake this DNA for a viral infection and trigger an immune response called the type I interferon response. This puts the stem cells in a dormant state and stops the production of new neurons.

“This response is actually very good for stem cells, as the external environment is not ideal for newly born neurons,” explained Dr. Pike. “When new cells are created under these stressful conditions, they are killed. It is better to keep the stem cells dormant and wait until the stress is gone to generate neurons.”

This study may help explain why certain versions of FOXO3 are associated with a very long and healthy life-they may help people maintain adequate reserves. There is .. It may also help explain why regular exercise that boosts FOXO3 helps maintain mental sharpness. However, Dr. Pike warned that it was too early to know if this new information could be used to create new treatments. sick.

“It may be a double-edged sword,” explained Dr. Pike. “Excessive activation of FOXO3 can be very harmful. We don’t want to keep this all the time.”

To better understand the processes involved, she and her colleagues discuss how FOXO3 is regulated and whether it is beneficial to health to turn it on or off for a short period of time. I will continue to study.


Brain enzymes found to activate dormant neural stem cells provide insight into neurodevelopmental disorders


For more information:
Inaphan and other cell stress signaling activates type I IFN responses through post-translational modification of lamin regulated by FOXO3. Nature Communications (2021). DOI: 10.1038 / s41467-020-20839-0

Quote: Research reveals how longevity genes protect brainstem cells from stress (2021, February 19) https://medicalxpress.com/news/2021-02-reveals-longevity-gene- Obtained from brain-stem.html on February 19, 2021

This document is subject to copyright. No part may be reproduced without written permission, except for fair transactions for personal investigation or research purposes. The content is provided for informational purposes only.

What Are The Main Benefits Of Comparing Car Insurance Quotes Online

LOS ANGELES, CA / ACCESSWIRE / June 24, 2020, / Compare-autoinsurance.Org has launched a new blog post that presents the main benefits of comparing multiple car insurance quotes. For more info and free online quotes, please visit https://compare-autoinsurance.Org/the-advantages-of-comparing-prices-with-car-insurance-quotes-online/ The modern society has numerous technological advantages. One important advantage is the speed at which information is sent and received. With the help of the internet, the shopping habits of many persons have drastically changed. The car insurance industry hasn't remained untouched by these changes. On the internet, drivers can compare insurance prices and find out which sellers have the best offers. View photos The advantages of comparing online car insurance quotes are the following: Online quotes can be obtained from anywhere and at any time. Unlike physical insurance agencies, websites don't have a specific schedule and they are available at any time. Drivers that have busy working schedules, can compare quotes from anywhere and at any time, even at midnight. Multiple choices. Almost all insurance providers, no matter if they are well-known brands or just local insurers, have an online presence. Online quotes will allow policyholders the chance to discover multiple insurance companies and check their prices. Drivers are no longer required to get quotes from just a few known insurance companies. Also, local and regional insurers can provide lower insurance rates for the same services. Accurate insurance estimates. Online quotes can only be accurate if the customers provide accurate and real info about their car models and driving history. Lying about past driving incidents can make the price estimates to be lower, but when dealing with an insurance company lying to them is useless. Usually, insurance companies will do research about a potential customer before granting him coverage. Online quotes can be sorted easily. Although drivers are recommended to not choose a policy just based on its price, drivers can easily sort quotes by insurance price. Using brokerage websites will allow drivers to get quotes from multiple insurers, thus making the comparison faster and easier. For additional info, money-saving tips, and free car insurance quotes, visit https://compare-autoinsurance.Org/ Compare-autoinsurance.Org is an online provider of life, home, health, and auto insurance quotes. This website is unique because it does not simply stick to one kind of insurance provider, but brings the clients the best deals from many different online insurance carriers. In this way, clients have access to offers from multiple carriers all in one place: this website. On this site, customers have access to quotes for insurance plans from various agencies, such as local or nationwide agencies, brand names insurance companies, etc. "Online quotes can easily help drivers obtain better car insurance deals. All they have to do is to complete an online form with accurate and real info, then compare prices", said Russell Rabichev, Marketing Director of Internet Marketing Company. CONTACT: Company Name: Internet Marketing CompanyPerson for contact Name: Gurgu CPhone Number: (818) 359-3898Email: [email protected]: https://compare-autoinsurance.Org/ SOURCE: Compare-autoinsurance.Org View source version on accesswire.Com:https://www.Accesswire.Com/595055/What-Are-The-Main-Benefits-Of-Comparing-Car-Insurance-Quotes-Online View photos



Pictures Credit

ExBUlletin

to request, modification Contact us at Here or [email protected]