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Dear Dr. Roach: COVID Vaccine and Pregnancy | Health

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Dr. Keith Roach


DR.Key slaughter for Herald & Review

Dear Dr. Cockroach: What do you think about the COVID-19 vaccine during pregnancy? I read that it is safe. Can you explain how? I have a minimal understanding of mRNA vaccines and not how they affect pregnancy.

A: Pregnant women are unlikely to be infected with COVID-19, but are more likely to have complications from COVID-19. Pregnancy affected by COVID-19 increases both preterm birth rate and the need for caesarean section compared to uninfected women. Fortunately, over 90% of infected pregnant women recover from COVID-19 before childbirth. Nevertheless, pregnant women are likely to require intensive care and mechanical ventilation, so protection should be a top priority.

Because the vaccine is brand new, there are no solid safety data on the use of the vaccine during pregnancy (pregnant women are excluded from the vaccine trial). However, expert opinion is generally on the side of recommending vaccines. The mRNA vaccine produced by Moderna and Pfizer does not contain live viruses. The mRNA vaccine works by “transmitting” to the muscle cells of the arm where the vaccine is injected, producing a viral protein called the spike protein. “MRNA” is an abbreviation for “messenger RNA”. This is how DNA encodes the instructions for making proteins. mRNA cannot be part of a human cell because it lasts only for a short period of time in the body and is destroyed by the body’s own mechanism shortly after the cell makes the spike protein. The body learns to recognize peplomer proteins as foreign invaders, which act as primers for the body’s immune system. Long after the peplomer produced after vaccination with muscle cells was destroyed, B cells and T cells were quick and effective in destroying the virus before it caused disease when a person was exposed to the virus. Remember how to initiate a typical response. Neither mRNA nor peplomer poses a risk to the developing foetation.

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