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Israeli breakthroughs help make cancer-free drugs

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A team of Israeli researchers has introduced a new technological approach that may lead to faster development of antineoplastic drugs, independent of animal testing.

Professor Yaakov Nahmias, director of the Glass Center for Bioengineering at the Hebrew University of Jerusalem, founder of Tissue Dynamic, and research leader, explains: The main reason for these failures is that clinical trials are ultimately based on minimal information obtained from animal studies and often cannot reproduce human reactions. “

The main animals used in drug development are rodents, mice, and rats, which differ in genetics, physiology, and metabolism from humans, and successful treatment in rodents often fails in clinical trials. ..

A team at the Hebrew University has developed human-on-chip technology using human tissue in a device that mimics human physiology. Although this type of technology has been around for over 30 years, Nahmias’s study incorporates microscopic sensors into the human tissue itself, allowing teams to accurately monitor the body’s response to specific medications.

“Our technology is unique in that it can go beyond what was previously possible in animal testing. Microsensors that provide real-time data on how drugs work and when they stop working. You can now insert it, “says Nahmias.

Using this new technology, researchers have been able to show that the commonly used anticancer drug cisplatin causes dangerous fat accumulation in the human kidneys. Chemotherapy treatment is then combined with another drug, empagliflozin (Jardiance), to limit the absorption of sugar in the kidneys, reduce the harmful accumulation of fat, and cause kidney damage experienced by cancer patients during treatment. Was able to be minimized.

This application was the first to develop a drug protocol using a bionic chip while avoiding the traditional reliance on animal testing.

“This breakthrough technology has the potential to significantly reduce drug testing and manufacturing time while avoiding the need to test animals in the laboratory. This allows time, money, and certainty. You can save unnecessary pain on your skin, “says The Hebrew University.

Tissue Dynamic is currently in clinical trials and is working towards regulatory approval of certain drugs as a new treatment for cancer.

Reprinted with permission from TPS..

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