Connect with us


Researchers report a zoonotic spread of SARS-CoV-2 adapted from mink to humans




Now available in recent reports bioRxiv* Preprint server, Polish and Finnish researchers Spillover event Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) adapted to mink, transmitted from cultured mink to humans after extensive adaptation process.

Research: SARS-CoV-2 zoonotic disease: mink-adaptive virus in humans. Image Credits: Inspiration / Shutterstock

Even before the ongoing pandemic of coronavirus disease 19 (COVID-19), coronavirus was already known as a zoonotic pathogen. SARS-CoV-2 is actually the third most pathogenic member of the family to Century (after SARS-CoV and MERS-CoV virus).

Also, mass vaccination against COVID-19 is currently underway at the global level, but it is not yet known how this pandemic (and its causative virus) will end. In other words, the highly advertised concepts of herd immunity and virus eradication are considered increasingly unrealistic, taking into account prevalence, genetic diversity, and endemic animal depots. I will.

It has been reported that various mammalian species around the world carry SARS-CoV-2. Especially dogs, cats, cats, minks, ferrets and deer. In addition, SARS-CoV-2 infection was recently identified in farmed mink in European countries.

More specifically, infected mink-to-human viral transmission cycles have been reported in the Netherlands and Denmark. These findings are of particular importance to Poland, Europe’s second largest producer of mink fur.

This is a Polish and Finnish researcher led by Dr. Lukasz Rabalski of the Department of Inter-University Biotechnology at the University of Gdansk and the University of Gdansk Medical School in Poland to evaluate whether there is a ripple effect of SARS-CoV-2 from farming. That’s why I aimed. Mink to humans.

From prevalence assessment to detailed sequence

This research group (along with other independent groups) recently showed active SARS-CoV-2 infection in farmed mink in northern Poland in mid-November 2020. Discarded the possibility of contamination.

The latest data obtained and deposited by the National Institute of Veterinary Medicine in Poland showed the presence of SARS-CoV-2 mutants from animals on the same farm.However, after that Phylogenetic analysis The virus has been shown to belong to the B.1.1.279 strain (scale armor classification), which was not surprising given its spread in Europe.

In this study, SARS-CoV-2 genome sequencing was performed at the University of Gdansk, Poland, using sample-containing RNA isolated from positive swabs (ie, two target genes by reverse transcription polymerase chain). amplification). reaction).

The resulting reads were base-called, bar-coded, and trimmed to remove adapter, barcode, and primer sequences, and specific ARCTIC pipeline software was used to generate the SARS-CoV-2 genome. It was.Finally, phylogenetic analysis was performed using a procedure highlighted in an open source project known as

Close clustering and mutations

In the current study, cases of infection with mink-adapted SARS-CoV-2 mutants were reported in asymptomatic human hosts. Phylogenetic analysis showed that this particular virus clustered closely with virus isolates from mink.

In addition, researchers have discovered that there are four mutations in the gene. Spike protein Not only (including the Y453F mutation previously reported to have appeared in mink), but also other mutations in isolates obtained from SARS-CoV-2 positive patients.

We tested the hypothesis that mutations specific to mink-adapted mutants are present in the viral genome sequence and that the potential pathways for contraction are from animals. There were also new mutations previously unobserved in SARS-CoV-2 isolates worldwide. This actually truncates the open reading frame (ORF) 7b at position L22.

Epidemiological consideration

The new mutants described in this study underscore the adaptation of SARS-CoV-2 to animal hosts, with specific point mutations being modified early in the inter-animal infection cycle and additional. Changes accumulate over time.

The exact role of mutations should be determined, but they may increase the fitness of new hosts, “says the study’s authors. “It remains unclear whether these characteristics alter the infectious course of the disease or the immunogenicity of humans.”

In any case, this variant requires careful monitoring of the general public. These results basically confirm the need for national animal monitoring and in-depth genetic analysis of SARS-CoV-2 positive patients.

*Important Notices

bioRxiv publishes unpeer-reviewed preliminary scientific reports and should not be considered definitive, guide clinical / health-related behaviors, or be treated as established information.


What Are The Main Benefits Of Comparing Car Insurance Quotes Online

LOS ANGELES, CA / ACCESSWIRE / June 24, 2020, / Compare-autoinsurance.Org has launched a new blog post that presents the main benefits of comparing multiple car insurance quotes. For more info and free online quotes, please visit https://compare-autoinsurance.Org/the-advantages-of-comparing-prices-with-car-insurance-quotes-online/ The modern society has numerous technological advantages. One important advantage is the speed at which information is sent and received. With the help of the internet, the shopping habits of many persons have drastically changed. The car insurance industry hasn't remained untouched by these changes. On the internet, drivers can compare insurance prices and find out which sellers have the best offers. View photos The advantages of comparing online car insurance quotes are the following: Online quotes can be obtained from anywhere and at any time. Unlike physical insurance agencies, websites don't have a specific schedule and they are available at any time. Drivers that have busy working schedules, can compare quotes from anywhere and at any time, even at midnight. Multiple choices. Almost all insurance providers, no matter if they are well-known brands or just local insurers, have an online presence. Online quotes will allow policyholders the chance to discover multiple insurance companies and check their prices. Drivers are no longer required to get quotes from just a few known insurance companies. Also, local and regional insurers can provide lower insurance rates for the same services. Accurate insurance estimates. Online quotes can only be accurate if the customers provide accurate and real info about their car models and driving history. Lying about past driving incidents can make the price estimates to be lower, but when dealing with an insurance company lying to them is useless. Usually, insurance companies will do research about a potential customer before granting him coverage. Online quotes can be sorted easily. Although drivers are recommended to not choose a policy just based on its price, drivers can easily sort quotes by insurance price. Using brokerage websites will allow drivers to get quotes from multiple insurers, thus making the comparison faster and easier. For additional info, money-saving tips, and free car insurance quotes, visit https://compare-autoinsurance.Org/ Compare-autoinsurance.Org is an online provider of life, home, health, and auto insurance quotes. This website is unique because it does not simply stick to one kind of insurance provider, but brings the clients the best deals from many different online insurance carriers. In this way, clients have access to offers from multiple carriers all in one place: this website. On this site, customers have access to quotes for insurance plans from various agencies, such as local or nationwide agencies, brand names insurance companies, etc. "Online quotes can easily help drivers obtain better car insurance deals. All they have to do is to complete an online form with accurate and real info, then compare prices", said Russell Rabichev, Marketing Director of Internet Marketing Company. CONTACT: Company Name: Internet Marketing CompanyPerson for contact Name: Gurgu CPhone Number: (818) 359-3898Email: [email protected]: https://compare-autoinsurance.Org/ SOURCE: Compare-autoinsurance.Org View source version on accesswire.Com:https://www.Accesswire.Com/595055/What-Are-The-Main-Benefits-Of-Comparing-Car-Insurance-Quotes-Online View photos

Pictures Credit


to request, modification Contact us at Here or [email protected]