Health
The effects of a high-fat diet can be combated by lowering levels of apolipoprotein CIII – Mental Daily
Recent studies published in the journal Science We have determined that the potentially harmful effects of eating a high-fat diet can be addressed by lowering the levels of apolipoprotein CIII.
Researchers at the Karolinska Institute studied 8-week-old rodents and fed controls in the same age range with a high-fat diet and a regular diet.
“One of the high-fat diet groups received so-called antisense (ASO) treatment 10 weeks after the diet to lower apoCIII levels, and the other group was already treated with ASO from the beginning, so apoCIII. Prevented the increase in the number of people, “said the research news release.
Researchers have shown that high levels of apolipoprotein CIII are associated with severe health conditions such as type 2 diabetes and cardiovascular disease.
After a 10-week span, the rodents in the high-fat diet group developed serious conditions such as obesity and insulin resistance. However, after treatment with ASO, their condition normalized and glucose metabolism returned to pre-state levels.
“In the group treated directly with ASO from the beginning, the development of metabolic disorders was prevented and animals showed the same body composition and metabolism as control mice on a normal diet,” the researchers wrote in a news release. ..
“The underlying mechanisms of apoCIII-lowering therapy include increased lipase enzyme activity and receptor-mediated uptake of lipids into the liver. Fatty acids are produced by fatty acid oxidation in the liver, called the ketogenic pathway. It was transferred to a chemical process and then converted to ketones used for heat production in brown adipose tissue. “
Based on the findings, the research group shows that despite a high-fat diet, low levels of apolipoprotein CIII can combat the potentially detrimental effects of fat-induced metabolic disorders through increased insulin sensitivity. I was able to.
“Reducing apoCIII protects and reverses the HFD-induced metabolic phenotype by promoting physiological insulin sensitivity,” the researchers conclude in a journal report.
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