A team of researchers in India and the United States have confirmed that rapamycin, a drug commonly used to prevent transplant organ rejection by suppressing the body’s immune system, can be reused to treat patients with Covid-19. .. Researchers say the diversion of rapamycin is similar to using remdesivir (originally developed to treat hepatitis C) in the fight against Covid-19. This study was conducted by the Indian Institute of Science Education and Research (IISER) Bhopal and the University of Nebraska Medical Center (Nebraska).
According to a peer-reviewed research paper by the reputed international Elsevier journal Chemico Biological Interactions, researchers have shown that the biochemical effects of rapamycin drug molecules show their promise in the treatment of Covid-19. ..
The reused drug (rapamycin) is undergoing clinical development processes and toxicity studies for the treatment of other diseases, thus avoiding many steps in preclinical and early clinical development. Therefore, the above drugs can be tested directly in COVID-19 subjects in Phase II trials.
Dr. Amjad Husan, Principal Scientist and CEO of IISER Bhopal, said drug repositioning is an attractive solution given the time-consuming development of new drugs given the rampant pandemic.
One of the main challenges in the development of antiviral drugs COVID-19 (new coronavirus infection) (# If there is no character limit, add parentheses when it first appears It is a widespread mutation that the virus receives and therefore the drug is considered ineffective. However, treatment with drugs such as rapamycin is said to not face the problem because it acts on the host protein rather than the virus. Rapamycin can also inhibit protein synthesis and block viral replication, regardless of the type of mutant.
Apart from inhibiting protein synthesis, this study shows that rapamycin inhibits the immune system protein, pro-inflammatory cytokines. High levels of cytokines in the blood exhibit a medical phenomenon called “cytokine storms.” In this phenomenon, the body not only fights the virus, but also begins to attack its own cells and tissues. Studies add that the inhibitory effect of rapamycin on cytokines is also a promising treatment for COVID-19.
Rapamycin is also known to reduce obesity through a variety of pathways, which helps reduce the severity of the effects of COVID-19 in obese people. In addition, the drug is known to induce autophagy, a cell recycling process that helps eliminate damaged proteins and delay aging. Given the high mortality rate of the elderly, studies argue that the anti-aging properties of rapamycin may provide a protective effect against the pathological conditions induced by COVID-10.
Another study was recently published in the prestigious journal The Lancet-Healthy Longevity, suggesting the possibility of a rapamycin analog (rapalog) that enhances resilience to SARS-CoV-2 infection and reduces the severity of COVID-19. Did.
Successful vaccination promotion may control the infection, but it will not go away. Currently, there are no globally approved drugs for the treatment of COVID-19.
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