Connect with us

Health

Research may lead to a more sophisticated approach to head and neck cancer

Published

on

 


By targeting enzymes that play important roles in head and neck cancer cells, UCLA dentistry researchers have significantly slowed the growth and spread of tumors in mice, and the immunotherapy often received by these types of cancers. I was able to increase the effectiveness. It is resistant.

Their findings published online in the journal Molecular cellMay help researchers develop more sophisticated approaches to combat highly invasive head and neck squamous epithelial cancers that primarily affect the mouth, nose, and throat.

Immunotherapy, which is used as a clinical treatment for various cancers, utilizes the body’s natural defenses to fight the disease. However, some cancers, including head and neck squamous epithelial cancer, are less responsive to treatment than other cancers. The prognosis for these head and neck cancers is poor, the 5-year survival rate is high, and effective treatment is urgently needed.

The UCLA research team, led by Dr. Cun-Yu Wang, a prominent professor of oral biology at the University of Dental School, said tumors to immunotherapy by targeting tumor replication and the vulnerability of immune cell processes It has been shown that it may affect the reaction of cells.

The enzyme they focused on, KDM4A, is known as an epigenetic factor. It is a molecule that regulates gene expression, silences some genes in cells, and activates other genes. In head and neck cancer of squamous epithelial cells, overexpression of KDM4A promotes gene expression associated with cancer cell replication and diffusion.

It is well known that tumor cells can spread undetected by the immune system and can spread to lymph nodes or other parts of the body without supervision. In this case, tumor cells that develop in the epithelial layer that lines the structure of the head and neck can turn into head and neck squamous epithelial cancer if unchecked.

Cancer cell replication occurs through abnormal spread and activation of cancer cell signaling pathways, and researchers asked: If we can disrupt these processes and identify vulnerabilities, the body will fight against cancer cells. Is it possible to change the reaction of the body and the reaction to the outside? Immunotherapy?

We know that the KDM4A gene plays an important role in the replication and spread of cancer cells, so we focus on removing this gene and see if the opposite response is obtained. I did... “

Dr. Cun-Yu Wang, Research Author and Member of the Jonsson Comprehensive Cancer Center at the University of California, Los Angeles

By removing the KDM4A gene in their mouse model, researchers have witnessed a marked reduction in squamous cell carcinoma and much less cancer metastasis to the lymph nodes-a precursor to the spread of the disease throughout the body. ..

Surprisingly, they also found that removal of KDM4A also led to mobilization and activation of the fight against body infections. T cells, Killed cancer cells and stimulated endemic tumor immunity.

They then sought to clarify why squamous cell carcinoma cells were so unresponsive to immunotherapy treatment. In another series of mouse models, they again removed KDM4A and introduced PD-1 blockade. It signals the immunotherapeutic drug to attack the cancer cells. The combination of immunotherapy and KDM4A removal further reduced the growth of squamous cell carcinoma and lymph node metastasis.

Next, researchers tested whether small molecule inhibitors of KDM4A could be improved. Effectiveness of Original PD-1 blockade-based immunotherapy. They also found that inhibitors also helped to eliminate cancer stem cells associated with cancer recurrence.

This discovery holds promise for the development of more specific inhibitors and more effective cancer immunotherapies for KDM4A.

Dr. Paul Krebsbach, Dean and Professor of UCLA School of Dentistry, said: “The results of this study will have a significant impact on the development of more effective and life-saving cancer therapies.”

Source:

Journal reference:

Zhang, W. , et al.. (2021) Targeting KDM4A epigenetically activates tumor cell-specific immunity by inducing DNA replication stress...Molecular cell.. doi.org/10.1016/j.molcel.2021.02.038..

..

What Are The Main Benefits Of Comparing Car Insurance Quotes Online

LOS ANGELES, CA / ACCESSWIRE / June 24, 2020, / Compare-autoinsurance.Org has launched a new blog post that presents the main benefits of comparing multiple car insurance quotes. For more info and free online quotes, please visit https://compare-autoinsurance.Org/the-advantages-of-comparing-prices-with-car-insurance-quotes-online/ The modern society has numerous technological advantages. One important advantage is the speed at which information is sent and received. With the help of the internet, the shopping habits of many persons have drastically changed. The car insurance industry hasn't remained untouched by these changes. On the internet, drivers can compare insurance prices and find out which sellers have the best offers. View photos The advantages of comparing online car insurance quotes are the following: Online quotes can be obtained from anywhere and at any time. Unlike physical insurance agencies, websites don't have a specific schedule and they are available at any time. Drivers that have busy working schedules, can compare quotes from anywhere and at any time, even at midnight. Multiple choices. Almost all insurance providers, no matter if they are well-known brands or just local insurers, have an online presence. Online quotes will allow policyholders the chance to discover multiple insurance companies and check their prices. Drivers are no longer required to get quotes from just a few known insurance companies. Also, local and regional insurers can provide lower insurance rates for the same services. Accurate insurance estimates. Online quotes can only be accurate if the customers provide accurate and real info about their car models and driving history. Lying about past driving incidents can make the price estimates to be lower, but when dealing with an insurance company lying to them is useless. Usually, insurance companies will do research about a potential customer before granting him coverage. Online quotes can be sorted easily. Although drivers are recommended to not choose a policy just based on its price, drivers can easily sort quotes by insurance price. Using brokerage websites will allow drivers to get quotes from multiple insurers, thus making the comparison faster and easier. For additional info, money-saving tips, and free car insurance quotes, visit https://compare-autoinsurance.Org/ Compare-autoinsurance.Org is an online provider of life, home, health, and auto insurance quotes. This website is unique because it does not simply stick to one kind of insurance provider, but brings the clients the best deals from many different online insurance carriers. In this way, clients have access to offers from multiple carriers all in one place: this website. On this site, customers have access to quotes for insurance plans from various agencies, such as local or nationwide agencies, brand names insurance companies, etc. "Online quotes can easily help drivers obtain better car insurance deals. All they have to do is to complete an online form with accurate and real info, then compare prices", said Russell Rabichev, Marketing Director of Internet Marketing Company. CONTACT: Company Name: Internet Marketing CompanyPerson for contact Name: Gurgu CPhone Number: (818) 359-3898Email: [email protected]: https://compare-autoinsurance.Org/ SOURCE: Compare-autoinsurance.Org View source version on accesswire.Com:https://www.Accesswire.Com/595055/What-Are-The-Main-Benefits-Of-Comparing-Car-Insurance-Quotes-Online View photos



Pictures Credit

ExBUlletin

to request, modification Contact us at Here or [email protected]