Health
The study states that the “zombie gene” increases its activity over several hours after simulated death of a brain tissue sample.
They found a surprising amount of activity in genes specific to glial cells. Although they are part of the nervous system, these cells do not send or receive electrical signals. Instead, they support other brain cells, connect neurons, and help them function.
After simulated death, glial cells actually increased their genetic activity, swelling in size and growing long arms. The activity of these “zombie genes” peaked 12 hours after “death.” Other genes involved in brain activity, such as memory and thinking, were rapidly degraded, but other genes remained stable for approximately 24 hours without major changes.
It didn’t surprise the researchers. Glial cells act as a cleanup crew after events such as illness and brain injury, so scientists expected their genes to remain active.
However, researchers said that the amount of growth observed in glial cells generally affects brain science. Postmortem brain tissue is widely used because it is essential for brain research. However, past studies have not considered these post-mortem changes.
Researchers write that additional scrutiny is needed to properly interpret the results of postmortem brain studies.
“Most studies assume that when the heart stops beating, everything in the brain stops, but that’s not the case,” said Jeffrey Loeb, a professor at the University of Illinois at Chicago, who co-authored the treatise. .. news release.. “The good news from our findings is that we know which genes and cell types are stable, which are degraded, and which increase over time so that we can better understand the results of postmortem brain studies. That is. “
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