Health
Researchers are developing new tools that can detect Covid-19 and its variants
A team of scientists led by Singapore’s Nanyo University of Science and Technology (NTU) has designed a new diagnostic test that can detect Covid-19 even after it has been mutated.
This test is called the VaNGuard (Variant Nucleotide Guard) test. Studies show that new diagnostic tests utilize a gene editing tool known as CRISPR. It is widely used in scientific research to alter DNA sequences. It also modifies the genetic function and diagnostic applications of human cells under laboratory conditions.
According to researchers, the VaNGuard test can be used on coarse patient samples in the clinical setting without the need for RNA purification, with results in 30 minutes.
Tan Meng How, an associate professor of NTU’s Faculty of Chemistry and Biomedical Engineering, said: They can mutate, edit, or shuffle genetic material. This means that diagnostic tests may not catch them. As a result, we have put a lot of effort into developing a robust and sensitive test that can detect the virus even if the gene sequence is altered. “
“In addition, because frequent testing is essential to prevent the spread of the virus within the population, we have developed the tests quickly and affordably so that they can be deployed in resource-poor environments,” he adds. I did.
Researchers have made the test more viable by integrating the test into a specially processed piece of paper that resembles a pregnancy test.
Immerse a piece of paper in a tube containing a crude nasopharyngeal sample and reaction mixture.
The authors write that in the presence of the SARS-CoV-2 virus or its variants, two strong bands appear on pieces of paper. If no virus is present, only one band will be displayed.
Scientists have tested the ability of the VaNGuard test to detect SARS-CoV-2 mutants by synthesizing RNA samples with the same mutant sequences as known SARS-CoV-2 mutants.
This study was published in a scientific journal Nature Communications..
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