Connect with us


S’pore scientists have found new ways to improve breast cancer treatment outcomes, Singapore news and top stories




Singapore-Local scientists have found ways to use alternative drugs to combat resistance to the forms of targeted therapies used to treat patients with HER2-positive breast cancer.

Drugs often used to treat patients with this condition often stop functioning after a while, causing a recurrence.

Researchers at the National University of Singapore’s Institute for Cancer Science, the Singapore Genome Institute under the Institute of Science and Technology, the National University of Singapore Cancer Institute (NCIS), and Danish international collaborators, why this happened I looked it up.

A team led by Professor Lee Soon Chin of NCIS Singapore and Professor Yu Qiang of GIS focused on a protein called HER2 (Human Epidermal Growth Factor Receptor 2).

Scientists couldn’t figure out why, but drugs that targeted the HER2 protein often ended up ineffective.

To decipher the mechanism of cancer resistance to anti-HER2 therapy, the team used existing data from biochemical databases along with tumor samples from 29 patients enrolled in NCIS clinical trials.

They focused on the enzyme subunit known as PPP2R2B. It suppresses cancer by chemically modifying the signaling pathway.

Breast cancers that did not respond well to anti-HER2 therapy tended to have low levels of PPP2R2B enzyme.

In fact, the activity of the PPP2R2B enzyme was suppressed by another enzyme known as EZH2.

Plans to conduct clinical trials to test the effectiveness of the combination of both drugs to treat patients with HER2-positive breast cancer.

In addition, the PPP2R2B enzyme can be used as a potential predictive marker to identify patients who may be resistant to standard anti-HER2 therapy and may benefit from additional therapy.

Professor Lee, head and senior consultant at NCIS’s Department of Hematology and Oncology, said HER2-positive breast cancer accounts for 20-25% of all breast cancers.

“Despite its initial efficacy, resistance to anti-HER2 therapy almost always occurs in patients with advanced cancer and will eventually succumb to the disease,” she said.

“This study provides insight into why anti-HER2 drugs ultimately fail and provides solutions to restore susceptibility to anti-HER2 treatments that may prolong patient survival.”

What Are The Main Benefits Of Comparing Car Insurance Quotes Online

LOS ANGELES, CA / ACCESSWIRE / June 24, 2020, / Compare-autoinsurance.Org has launched a new blog post that presents the main benefits of comparing multiple car insurance quotes. For more info and free online quotes, please visit https://compare-autoinsurance.Org/the-advantages-of-comparing-prices-with-car-insurance-quotes-online/ The modern society has numerous technological advantages. One important advantage is the speed at which information is sent and received. With the help of the internet, the shopping habits of many persons have drastically changed. The car insurance industry hasn't remained untouched by these changes. On the internet, drivers can compare insurance prices and find out which sellers have the best offers. View photos The advantages of comparing online car insurance quotes are the following: Online quotes can be obtained from anywhere and at any time. Unlike physical insurance agencies, websites don't have a specific schedule and they are available at any time. Drivers that have busy working schedules, can compare quotes from anywhere and at any time, even at midnight. Multiple choices. Almost all insurance providers, no matter if they are well-known brands or just local insurers, have an online presence. Online quotes will allow policyholders the chance to discover multiple insurance companies and check their prices. Drivers are no longer required to get quotes from just a few known insurance companies. Also, local and regional insurers can provide lower insurance rates for the same services. Accurate insurance estimates. Online quotes can only be accurate if the customers provide accurate and real info about their car models and driving history. Lying about past driving incidents can make the price estimates to be lower, but when dealing with an insurance company lying to them is useless. Usually, insurance companies will do research about a potential customer before granting him coverage. Online quotes can be sorted easily. Although drivers are recommended to not choose a policy just based on its price, drivers can easily sort quotes by insurance price. Using brokerage websites will allow drivers to get quotes from multiple insurers, thus making the comparison faster and easier. For additional info, money-saving tips, and free car insurance quotes, visit https://compare-autoinsurance.Org/ Compare-autoinsurance.Org is an online provider of life, home, health, and auto insurance quotes. This website is unique because it does not simply stick to one kind of insurance provider, but brings the clients the best deals from many different online insurance carriers. In this way, clients have access to offers from multiple carriers all in one place: this website. On this site, customers have access to quotes for insurance plans from various agencies, such as local or nationwide agencies, brand names insurance companies, etc. "Online quotes can easily help drivers obtain better car insurance deals. All they have to do is to complete an online form with accurate and real info, then compare prices", said Russell Rabichev, Marketing Director of Internet Marketing Company. CONTACT: Company Name: Internet Marketing CompanyPerson for contact Name: Gurgu CPhone Number: (818) 359-3898Email: [email protected]: https://compare-autoinsurance.Org/ SOURCE: Compare-autoinsurance.Org View source version on accesswire.Com:https://www.Accesswire.Com/595055/What-Are-The-Main-Benefits-Of-Comparing-Car-Insurance-Quotes-Online View photos

Pictures Credit


to request, modification Contact us at Here or [email protected]