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Infant exposure to antibiotics can lead to the loss of T cells, which are essential for fighting allergens: Study

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Exposure to antibiotics in utero and infancy can lead to irreversible loss of regulatory T cells in the colon. Only six months later, this is a valuable component of the immune system’s response to allergens in later years, and new studies have been found. T cells are a type of white blood cell that is very important to the immune system and are the core of adaptive immunity, a system that regulates the body’s immune response to specific pathogens.

According to a study published in the journal mBio, the use of antibiotics early in life destroys the gut microbiota, the trillions of beneficial microbes that live inside and outside our body, leading to healthy maturation. It is already known to play an important role. For the immune system and prevention of diseases such as obesity and inflammatory bowel disease.

However, little is known about how disruption of the microbiota, which produces short-chain fatty acids that regulate T cells, affects T cells in the colon. “Study of neonatal exposure through a lactating mother shows how offspring acquire a maternal antibiotic-affected microbial flora. This is the CD41 T cell in the colon. It impairs the ability to generate pools and causes long-term damage. ” Martin Brother, a researcher at Rutgers University. “The results last into adulthood and impair the body’s ability to turn off allergic reactions,” Blaser added.

In this study, based on a mouse model, the team examined fetal and neonatal exposure to antibiotics through the mother during the prenatal and postnatal weeks, when microbial communities gather and are prone to confusion. Bacteria that are beneficial to the reduction affect the development of the newborn’s immune system. These effects were specific to the colon and were not observed in the lungs, upper gastrointestinal tract or spleen, the researchers said.

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