Connect with us

Health

New HIV Vaccine Candidates Can Become Game Changers

Avatar

Published

on


The human immunodeficiency virus (HIV) is a virus that attacks the body’s immune system. Over time, this can lead to acquired immunodeficiency syndrome, or AIDS. Although advances in HIV treatment using antiviral drugs have been successful in recent years, vaccine production is elusive. Scientists at the International AIDS Vaccine Initiative (IAVI) and Scripps Research have been working on approaches that have proven to be fruitful so far.

The researcher’s goal was to introduce a widely neutralizing antibody, or a vaccine that induces the production of bnAbs. These antibodies are widely referred to as neutralization because they can attach to a wide variety of HIV strains. However, to do this, you need to target rare immune cells called naive B cells. This vaccine is intended to be the first part of multi-step vaccine therapy to induce many types of bnAb.

In the Phase 1 clinical trial, there were 48 HIV-negative participants. Fact sheet.. Participants received two vaccines or placebo every two months. Participants were also divided into low-dose and high-dose groups. Of the vaccinated participants, 97% had detectable levels of target immune cells. According to the fact sheet, researchers believe these levels are “high enough to be considered promising for boosting as the next step.” Participants were monitored for 12 months after vaccination and had no safety concerns.

Anyway, the vaccine seems to have served its purpose.

“We and others need to start the process by triggering appropriate B cells, cells with special properties that give bnAb-secreting cells the potential to grow, in order to induce bnAb. “I assumed,” said Professor William Schief.Scripps Research Immunologist and Executive Director of Vaccine Design at IAVI’s Neutralizing Antibody Center (NAC), the laboratory that developed the vaccine. Press release..

“In this study, the target cells were about one millionth of all naive B cells. To get the right antibody response, you must first prime the right B cells. The data from this study show that the vaccine We have confirmed the ability of immunogens to do this. “


America is changing faster than ever! Add you a changing America Facebook Or twitter A feed to keep up with the news.


If the data are correct and the next phase of the clinical trial is successful, this could be a breakthrough in preventing HIV infection.

“Given the urgent need for HIV vaccines to curb the global epidemic, we believe these results will have broad implications for HIV vaccine researchers in deciding which scientific direction to pursue. “Masu,” said Mark Feinberg, president and CEO of IAVI.

“This is a huge achievement for vaccine science as a whole,” said Dennis Burton, director of science at the IAVI Neutralizing Antibody Center and professor at Scripps Research, director of the NIH Consortium for HIV / AIDS Vaccine Development.

According to the fact sheet, the group will begin further testing of the vaccine. There are also plans to work with Moderna to create an mRNA version of the vaccine aimed at inducing the production of the same bnAB.

Experts hope that this approach to HIV vaccines will also help other pathogens such as influenza virus, dengue virus, dicavirus, hepatitis C virus, and malaria parasites.

“This clinical trial has shown that not only HIV, but also the immune response can be stimulated in a predictable way to create new and better vaccines,” Burton said. “We believe that this type of vaccine engineering is more widely applicable and can bring a new day to vaccine science.”


Read more stories from changing America

Breakthrough researchers identify cancer cells by acidity

The fourth wave of COVID-19 in the Midwest hit “Category 5 Hurricane Status,” one expert said.

New bio-inks will allow scientists to print human organs

Lacrimal glands made in the laboratory can shed tears

A 22-year-old man receives the world’s first successful face transplant


..

What Are The Main Benefits Of Comparing Car Insurance Quotes Online

LOS ANGELES, CA / ACCESSWIRE / June 24, 2020, / Compare-autoinsurance.Org has launched a new blog post that presents the main benefits of comparing multiple car insurance quotes. For more info and free online quotes, please visit https://compare-autoinsurance.Org/the-advantages-of-comparing-prices-with-car-insurance-quotes-online/ The modern society has numerous technological advantages. One important advantage is the speed at which information is sent and received. With the help of the internet, the shopping habits of many persons have drastically changed. The car insurance industry hasn't remained untouched by these changes. On the internet, drivers can compare insurance prices and find out which sellers have the best offers. View photos The advantages of comparing online car insurance quotes are the following: Online quotes can be obtained from anywhere and at any time. Unlike physical insurance agencies, websites don't have a specific schedule and they are available at any time. Drivers that have busy working schedules, can compare quotes from anywhere and at any time, even at midnight. Multiple choices. Almost all insurance providers, no matter if they are well-known brands or just local insurers, have an online presence. Online quotes will allow policyholders the chance to discover multiple insurance companies and check their prices. Drivers are no longer required to get quotes from just a few known insurance companies. Also, local and regional insurers can provide lower insurance rates for the same services. Accurate insurance estimates. Online quotes can only be accurate if the customers provide accurate and real info about their car models and driving history. Lying about past driving incidents can make the price estimates to be lower, but when dealing with an insurance company lying to them is useless. Usually, insurance companies will do research about a potential customer before granting him coverage. Online quotes can be sorted easily. Although drivers are recommended to not choose a policy just based on its price, drivers can easily sort quotes by insurance price. Using brokerage websites will allow drivers to get quotes from multiple insurers, thus making the comparison faster and easier. For additional info, money-saving tips, and free car insurance quotes, visit https://compare-autoinsurance.Org/ Compare-autoinsurance.Org is an online provider of life, home, health, and auto insurance quotes. This website is unique because it does not simply stick to one kind of insurance provider, but brings the clients the best deals from many different online insurance carriers. In this way, clients have access to offers from multiple carriers all in one place: this website. On this site, customers have access to quotes for insurance plans from various agencies, such as local or nationwide agencies, brand names insurance companies, etc. "Online quotes can easily help drivers obtain better car insurance deals. All they have to do is to complete an online form with accurate and real info, then compare prices", said Russell Rabichev, Marketing Director of Internet Marketing Company. CONTACT: Company Name: Internet Marketing CompanyPerson for contact Name: Gurgu CPhone Number: (818) 359-3898Email: [email protected]: https://compare-autoinsurance.Org/ SOURCE: Compare-autoinsurance.Org View source version on accesswire.Com:https://www.Accesswire.Com/595055/What-Are-The-Main-Benefits-Of-Comparing-Car-Insurance-Quotes-Online View photos



Pictures Credit

ExBUlletin

to request, modification Contact us at Here or [email protected]