Health
Scientists say HIV and antiviral drugs have side effects in patients with coronavirus and will not cure
A Chinese study found that the HIV drug lopinavir / ritonavir and the antiviral drug Arbidol did not improve the condition in patients with mild to moderate illness coronavirus. Those patients who received HIV and antivirals did not improve faster compared to 86 patients treated without drugs in the study.
In addition, people who received antiviral drugs also reported side effects such as anorexia, nausea, and diarrhea.
Researchers do not recommend the use of these drugs as a treatment for COVID-19 because of side effects on patients. They recommend that researchers should continue to work to find effective treatments for COVID-19. However, at this time, scientists must take appropriate precautions, use strict guidelines and scientific clinical trials, and then make conclusions about antiviral therapies.
However, because they only tested the drug in patients with mild to moderate cases of infection, the researchers said it could have different effects on people with serious illness.
Lopinavir / ritonavir (LPV / r) was one of the most promising treatments for coronavirus after laboratory tests showed that it stopped replication of coronavirus. The NHS is currently testing this drug in the UK as part of RECOVERY, the largest COVID-19 trial.
According to Oxford University, the university is leading a study of five existing drugs in more than 6,000 patients nationwide. Daily email.
Also read: Trying to “flatten the curve” could be the worst way to combat the COVID-19 pandemic: a study
Umifenovir, generic name Arbidol Soviet-era flu and cold remedy, commonly used in Russia and China. However, both arbidol and lopinavir are protease inhibitors that attach to viral molecules and prevent them from spreading and multiplying.
The latest research on these drugs was conducted by the Center for Infectious Diseases at Guangzhou 8th People’s Hospital in Guangzhou. They divided the 86 patients they had for the study into three groups.
The first group consisted of 34 volunteers, Lopinavir / ritonavirA second group of 35 patients received arbidol and the last group served as a control group and received supportive care.
They studied the results of three groups that came out after a week and 14 days. However, there is no difference between groups in reducing fever, reducing cough, or improving lung inflammation, according to co-lead author of the study and Linghua Li, deputy director of the Center for Infectious Diseases. Is shown.
The results were disappointing, said Ian Jones, a professor of virology at Reading University. Over time, many disappointing early drug trials began to appear, where the drugs were developed for a variety of viruses, not specifically targeted to coronaviruses.
But it’s too early to give up on drug testing. Ideally, drug treatment should be given at an early diagnosis when symptoms are not yet visible. When given at the appropriate time, these drug treatments may still affect the disease by improving recovery rates and limiting the spread of the virus.
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