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Many children with severe inflammatory disease did not show COVID-19 symptoms: study

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According to the largest analysis of US cases to date, many children who develop a mysterious inflammatory disease after COVID-19 infection do not show some of the traditional COVID-19 symptoms and develop within weeks of infection. Did.

the study The most experienced of the more than 1,700 infants and teens led by the Centers for Disease Control and Prevention (CDC) Asymptomatic or mild COVID-19 before the onset of the disease, called Pediatric Multisystem Inflammatory Syndrome (MIS-C).

The researchers evaluated 1,733 of the 2,090 cases of syndrome in people under the age of 20 reported to the CDC as of January.

Of the 1,075 patients for whom information on early COVID-19 illness was available, only 265 had symptoms at that time.

Most patients with MIS-C showed fever, signs of systemic inflammation, hypotension, and multiple organ failure. Over 90% of these adolescents experienced symptoms related to at least four organ systems, and 58% needed treatment in the intensive care unit.

The study, published in JAMA Pediatrics, found that MIS-C appeared 2-5 weeks after the first COVID-19 infection. The hyperinflammatory response coincided with peak antibody production weeks after the first SARS-CoV-2 infection.

Researchers found that 95 percent of patients developed MIS-C within 60 days of COVID-19 infection.

Although rare, MIS-C is serious. Approximately 38% of patients aged 0-4 years developed hypotension or shock, and approximately 44% were admitted to the intensive care unit.

Overall, respiratory symptoms such as cough, shortness of breath, and chest pain were reported in less than 30% of patients.

About 51% of patients had hypotension and 37% developed shock. Cardiac dysfunction, including the inability of the heart to pump properly, was reported in 31%.

However, in this study, a significantly higher proportion of patients who were not preceded by COVID-19 symptoms developed hypotension, shock, cardiac dysfunction and intensive care compared to patients with early coronavirus symptoms. I found out that I was hospitalized in the room.

To Another editorial Along with the study, Jennifer Blumental, a pediatric intensivist and pediatric infectious disease specialist at Boston Children’s Hospital, said that pediatricians would ensure that their children were free of MIS-C risk. -19 Indicates that the lack of symptoms should not be taken. ..

“If the entire world’s pediatric population is at risk for COVID-19 and vaccination is delayed in the pediatric population compared to adults, this potentially serious consequence will be around the world until further results are available. We must stay at the forefront of differential diagnosis by pediatricians. Research. “

However, she said medical professionals could rest assured that younger patients had fewer cardiovascular complications and less hospitalization in the intensive care unit.

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