Connect with us

Health

New drug for brain disease: mRNA

Avatar

Published

on


Researchers at Tokyo Medical and Dental University (TMDU) are demonstrating an mRNA delivery system that effectively produces BDNF protein in the rat brain to protect neurons from ischemia.

Tokyo-A lack of oxygen in the brain tissue known as ischemia leads to the death of the neurons that cause the stroke. Despite considerable research, there is currently no cure to successfully prevent neuronal cell death. Researchers at Tokyo Medical and Dental University (TMDU) are currently reporting how to deliver mRNA to produce therapeutic proteins that protect neurons. Their findings demonstrated in rats are published in Biomaterials.

Brain-derived neurotrophic factor (BDNF) is a protein that enhances the survival and function of neurons. However, BDNF is difficult to establish its therapeutic status because BDNF molecules are too large to cross the protective barrier of the brain and are rapidly removed from the central nervous system.

Therefore, researchers have devised a way to generate BDNF where it is most needed.

They designed a delivery system that contains BDNF messenger RNA (mRNA), the information molecule needed to make BDNF. Once the mRNA enters the cell, it can be used as a blueprint for making proteins.

Their system (known as mRNA nanomicelles) is a parcel of mRNA that resembles a small ball surrounded by polymer chains. Polymers help protect mRNA from molecules that can break it down and hide it from the immune system.

“In addition to protecting mRNA by providing containment, polymers allow us to control cargo release,” explains Yuta Fukushima, lead author of the study. “Choosing a polymer with specific properties ensures that mRNA is released when and where it is needed.”

The efficacy of mRNA therapy was tested in rats that experienced cerebral ischemia. Nanomicelles have been found to increase the survival of hippocampal neurons. In particular, nanomicelles showed better effects when administered 2 days after ischemia than when administered immediately. This shows that nanomicelles are expanding the opportunities to provide effective treatments.

In addition, long-term therapeutic effects were observed 20 days after ischemia when mRNA nanomicelles were administered on both days 2 and 5. In maze experiments, treated rats showed better spatial memory than untreated rats.

“We are very encouraged by the performance of our system,” said Keiji Itataka, the author of the study. “Our experiments have also shown that mRNA nanomicelles can not only prevent neuronal death, but also expand the potential treatment window. These findings will have a significant impact on the development of actual clinical therapies. I’m expecting it. “

What Are The Main Benefits Of Comparing Car Insurance Quotes Online

LOS ANGELES, CA / ACCESSWIRE / June 24, 2020, / Compare-autoinsurance.Org has launched a new blog post that presents the main benefits of comparing multiple car insurance quotes. For more info and free online quotes, please visit https://compare-autoinsurance.Org/the-advantages-of-comparing-prices-with-car-insurance-quotes-online/ The modern society has numerous technological advantages. One important advantage is the speed at which information is sent and received. With the help of the internet, the shopping habits of many persons have drastically changed. The car insurance industry hasn't remained untouched by these changes. On the internet, drivers can compare insurance prices and find out which sellers have the best offers. View photos The advantages of comparing online car insurance quotes are the following: Online quotes can be obtained from anywhere and at any time. Unlike physical insurance agencies, websites don't have a specific schedule and they are available at any time. Drivers that have busy working schedules, can compare quotes from anywhere and at any time, even at midnight. Multiple choices. Almost all insurance providers, no matter if they are well-known brands or just local insurers, have an online presence. Online quotes will allow policyholders the chance to discover multiple insurance companies and check their prices. Drivers are no longer required to get quotes from just a few known insurance companies. Also, local and regional insurers can provide lower insurance rates for the same services. Accurate insurance estimates. Online quotes can only be accurate if the customers provide accurate and real info about their car models and driving history. Lying about past driving incidents can make the price estimates to be lower, but when dealing with an insurance company lying to them is useless. Usually, insurance companies will do research about a potential customer before granting him coverage. Online quotes can be sorted easily. Although drivers are recommended to not choose a policy just based on its price, drivers can easily sort quotes by insurance price. Using brokerage websites will allow drivers to get quotes from multiple insurers, thus making the comparison faster and easier. For additional info, money-saving tips, and free car insurance quotes, visit https://compare-autoinsurance.Org/ Compare-autoinsurance.Org is an online provider of life, home, health, and auto insurance quotes. This website is unique because it does not simply stick to one kind of insurance provider, but brings the clients the best deals from many different online insurance carriers. In this way, clients have access to offers from multiple carriers all in one place: this website. On this site, customers have access to quotes for insurance plans from various agencies, such as local or nationwide agencies, brand names insurance companies, etc. "Online quotes can easily help drivers obtain better car insurance deals. All they have to do is to complete an online form with accurate and real info, then compare prices", said Russell Rabichev, Marketing Director of Internet Marketing Company. CONTACT: Company Name: Internet Marketing CompanyPerson for contact Name: Gurgu CPhone Number: (818) 359-3898Email: [email protected]: https://compare-autoinsurance.Org/ SOURCE: Compare-autoinsurance.Org View source version on accesswire.Com:https://www.Accesswire.Com/595055/What-Are-The-Main-Benefits-Of-Comparing-Car-Insurance-Quotes-Online View photos



Pictures Credit

ExBUlletin

to request, modification Contact us at Here or [email protected]