Health
New evidence links harmful oral bacteria with early signs of Alzheimer’s disease
Neurodegeneration associated with Alzheimer’s disease often takes 10 or 20 years before clinical signs of cognitive decline become apparent. Identifying these early preclinical stages of Alzheimer’s disease remains very difficult for researchers. One hypothesis that is slowly building interesting evidence suggests that periodontal disease may be an early cause of neurodegeneration in Alzheimer’s disease.
New research weights that hypothesis and finds a strong link between bacterial imbalances in the oral microbiome and key biomarkers for Alzheimer’s disease. In previous studies Alzheimer’s disease and periodontal diseaseThis new study focused on the relationship between cerebrospinal fluid amyloid beta levels and the amount of various bacterial species in cognitively healthy elderly people. Toxic accumulation of a protein called amyloid beta in the brain is one of the important pathological signs of neurodegeneration in Alzheimer’s disease.
The new study recruited 48 cognitively healthy subjects over the age of 65. Amyloid cerebrospinal fluid (CSF) levels were matched against bacterial samples taken from under the gums. Low amyloid CSF levels are known to correlate with increased amyloid accumulation in the brain.
The results revealed that subjects with signs of high levels of amyloid deposits in the brain were more likely to have an imbalance in the gingival bacterial population.A large amount of harmful oral bacteria, etc. Prevotella, Porphyromonas, And Fretibacterium, Correlates with low levels of amyloid in CSF.
“As far as we know, this is the first study to show an association between the disproportionate bacterial community below the gingival line and the CSF biomarker for Alzheimer’s disease in cognitively normal older people.” The lead author of the study, Angela Kamer, said.
Kammer said her team’s findings show that the relationship between Alzheimer’s disease and the oral microbiota is not dominated by a single bacterial species, but a broader “imbalance” between good and bad bacteria. It states that it suggests.
“Our results show the importance of the overall oral microbiome in the role of” good “bacteria as well as” bad “bacteria in regulating amyloid levels,” adds Kamer. “These findings suggest that multiple oral bacteria are involved in the development of amyloid lesions.”
Moni J. de Leon, senior author of the new study, Oral bacteria and neurodegeneration Still unknown.Animal testing suggests Periodontal disease can amplify the inflammatory condition Although in other parts of the body, further research is needed to determine whether bacteria in the mouth can directly cause brain disorders such as Alzheimer’s disease.
“Cerebral amyloid levels accumulate and the mechanisms associated with Alzheimer’s disease are complex and only partially understood,” says Deleon. “This study supports the understanding that pro-inflammatory diseases interfere with the clearance of amyloid from the brain because the retention of amyloid in the brain can be estimated from CSF levels.”
The research team hopes to focus on this link between oral bacteria and cerebral amyloid accumulation in future research. Clinical trials are currently planned to investigate whether rigorous removal of plaque and tartar around the gums can directly reduce or prevent the accumulation of amyloid in the brain.
New study published in journal Alzheimer’s disease and dementia: diagnosis, evaluation, disease monitoring.
Source: NYU
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