The World Health Organization warns that none of the antibiotics currently being developed for antimicrobial resistance are sufficient to tackle drug-resistant strains that are expected to kill millions by 2050. I will.
In a report released Thursday, WHO stated that none of the 43 such drugs in the pipeline addressed the 13 most dangerous super bugs it identified.
Antimicrobial resistance (AMR) is described by experts as a silent pandemic.Studies show that the epidemic of drug-tolerant bugs kills about 700,000 people annually, a figure that 10m by 2050 — The life claimed by the same number of cancers each year.
Observers and industry members have stated that the current pandemic could warn the world of the dangers of under-investment in new drug research, but progress is hampered by one serious problem: AMR drugs It should be used as sparingly as possible and has few commercial incentives for pharmaceutical companies to invest in research and development.
According to a 2020 report, the antibiotic pipeline is “almost static,” with very few new drugs approved by regulators in recent years. Most of these are variations of the antibiotic class discovered in the 1980s that offer little advantage over existing ones. Many pharmaceutical companies have completely abandoned the development of antibiotics due to the unprofitable development of antibiotics.
Bacteria that cause pneumonia and sepsis are becoming more and more resistant to existing drugs, and this process is due to the abuse of antibiotics in humans and animals, according to Peter Beyer, Interim Head of Global Coordination for AMR at WHO. It is accelerating. The effects of AMR are most pronounced in poor countries and among the elderly and young children. For example, about 30% of newborns with sepsis die because the infection can tolerate multiple antibiotics.
The innovation cycle that replaces treatments is “broken,” Bayer said. “In the next few years, few innovative antibacterial treatments will appear on the patient’s bedside, and even fewer are targeting the most dangerous resistant strains.”
The report also highlights a new class of promising therapies, including phage — a virus that devours bacteria. Antibodies; immunotherapy that weakens the effects of bacteria.There is also a number of Aimed initiative Encourage investors and businesses to take action.
Still, scientists argue that delays in behavior can be costly, as antibiotics are so prevalent and used to treat a variety of infections in key medical environments. doing.
“We may soon be heading into the post-antibiotic era, where simple wounds and dental infections can be fatal,” said Hatim Sati, another member of the WHO Task Force. Said. “That’s what’s at stake here.”
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