Health
Epigenetic donations for everyone affect the severity of COVID-19
COVID-19, caused by infection with the SARS-CoV-2 virus, has changed people’s behavioral patterns since the moment of the pandemic. To date, more than 136 million people have suffered from the disease, of which more than 2.9 have died. Symptoms of infections range from those without clinical symptoms to those who need to be admitted to the intensive care unit with the help of emergency assisted ventilation.
At this time, the factors responsible for this widespread clinical picture are still unknown.Well, the article EBioMedicine-LancetA sister journal of lab findings shows that epigenetic donations for everyone affect the severity of COVID-19.
The study was conducted by a team led by Manel Esteller, director of the Josep Carreras Leukemia Research Institute (IJC) and ICREA research professor, who is also a professor of physiology at UB, and Aurora Pujol, who is also an ICREA professor and head of ICREA. It was carried out. IDIBELL Neurometabolic Disease Group.
Given the large number of infected people in the world whose health systems are saturated, there is a need for a way to predict whether a particular person’s infection requires hospitalization or can be controlled outpatiently. I will.
For now, we know that the coexistence of old age and other medical conditions (cardiovascular disease, obesity, diabetes, immunodeficiency) is associated with more serious infections. But what about the rest of the population?
This was a question raised by researchers. “To work on the study, we decided to study more than 400 patients who were positive for COVID-19 and did not belong to any risk group, and analyzed them according to their presence of genetic material. If, or if these were mild, or if you need respiratory assistance and need to be hospitalized, “says Manel Esterer.
“Research Results-Researchers Continue-Shows Epigenetic Changes in Chemical Switches that Modulate DNA Activity in Virus-Positive Patients with Severe COVID-19.” These modifications occur primarily in genes associated with excessive inflammatory responses and in genes that generally reflect poor health.
Interestingly, 13% of the world’s population exhibits this epigenetic feature (EPICOVID). Therefore, this is the group at greatest risk that we must pay special attention to. “
Manel Esteller, Professor of Physiology, University of Barcelona
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