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British researchers try to reinfect people with the coronavirus for science

 


Windsor Castle in Windsor, England

Windsor Castle in Windsor, England
Photo: Kirsty Wigglesworth (((AP).

U.S. researchers Kingdom Asking people Before Contracted with covid-19 to volunteer for the last one mission: allow themselves to be deliberately exposed to the coronavirus again. Scientists hope that their research will help better understand the limitations of innate immunity, including the risk of reinfection.

From the early days of the pandemic, there was concern that innate immunity to the virus would diminish in a significant number of people in a relatively short period of time. There are many confirmed cases of reinfection, such as a second death or exacerbation of the disease...But some studies Suggestion Reinfection is generally rare among survivors within the first 3 months of infection, while other studies conclude that immunity needs to be maintained. Up to 8 months or more.

Almost all studies on reinfection to date are based on laboratory or observational data.But some scientists at Oxford University take Different approaches to study covid-19 through human challenge testing. In February, they deliberately began exposing young, healthy volunteers to the virus in the hope of tracking the natural progression of the infection. This Monday, they began a similar study with young, healthy people who already had covid-19.

Helen McShane, a vaccinologist at Oxford University and lead scientist for the new project, said: statement University announced.. “Reinfecting these participants gives you an exact picture of how your immune system responded to the first COVID infection, when the second infection occurred, and how much virus you were infected with. In addition to gaining a basic understanding, this can help design tests that can accurately predict whether people are protected. “

This study works in two phases with two different groups. First stage expected to hire up to 64 people between the ages of 18 and 64 34, try to figure out the lowest dose of virus Fifty percent of volunteers needed to be successfully re-infected with little or no symptoms. After that, they will be quarantined for at least 17 days. People who develop symptoms are given monoclonal antibody therapy developed by Regeneron. The second phase, which should take place later this summer, exposes all volunteers to their pre-established viral load and records what happened to them.

Human challenge trials have been used regularly to study infectious diseases in the past.But some scientists and ethicists Fighted Human challenge exams may not be suitable for covid-19 studies. This is because even young and healthy people are new illnesses with potential unknown risks. Man..Still, both exams have been cleared by organizations such as the UK and 1Day Sooner. Claim Identifying tens of thousands of potential volunteers who are willing to participate in these exams around the world.

If these challenge trials work as intended, they are expected to provide valuable information on how to better develop new vaccines and treatments. For covid-19 to move forward.

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