Brazil COVID-19 variant is more contagious, has the potential to evade immunity, discovers new research | Weather Channel-Weather Channel Articles

According to researchers, a Brazilian variant (also known as P1) is more contagious than previous strains of coronavirus and may evade the immunity gained from infection with other strains.

Teams from Brazil, the United Kingdom, and the University of Copenhagen have estimated that the city of Manaus, Brazil, “has an aggressive variant of the coronavirus called P1 that seems to be the cause of the problem.”

“According to our analysis, P1 appeared in Manaus around November 2020. In just 7 weeks, it became undetectable in the genetic sample, accounting for 87% of the positive samples. Then other in Brazil. Some states and many other countries in the world. ” Samir Bhatt, a researcher at the Faculty of Public Health at the University of Copenhagen, said.

Survey results published in the journal ScienceShowed that P1 was 1.7 to 2.4 times more likely to be transmitted than non-P1 strains of coronavirus. P1 could also evade 10-46 percent of the immunity gained from non-P1 coronavirus infection.

In this study, the team used many forms of data from Manaus to characterize P1 and its properties, including 184 samples of gene sequence data. They found that, genetically speaking, P1 was different from previous coronavirus strains. We have acquired 17 mutations, including 3 important mutations in the spike protein (K417T, E484K, N501Y).

Researchers also used epidemiological models to estimate how contagious P1 was. In addition to estimating the signs of P avoiding immunity obtained from previous infections. The model compared two different virus strains. One is the “normal coronavirus” and the other is dynamically tuned using machine learning to best fit the actual event in Brazil.

The city of Manaus was so devastated by the first wave of 2020 that it was actually considered one of the few places in the world to reach herd immunity. An estimated 75% of the city’s population was infected. But then a second wave struck in November and December. The massive second wave killed many people every day and disrupted the healthcare system.

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