Connect with us


How Harvard’s new “lung-on-a-chip” model is driving COVID-19 drug discovery




One of the challenges facing scientists looking for new ways to combat COVID-19 is how effective they are in the human respiratory tract, even when pitching drug candidates against the virus in cell culture. It is not possible to accurately predict whether it is. Two Harvard teams have developed a new lung-on-chip model that they believe can solve the problem. One of them has already discovered an existing drug that could be reused in the fight against COVID-19.

A team led by the Wyss Institute for Biologically Inspired Engineering at Harvard University uses a microfluidic device designed to mimic the human lung airways, and the antimalarial drug amodiaquine causes COVID-19 SARS-CoV- 2 We found that it prevented the virus from invading lung cells. The researchers tested the results in a small animal model of the virus, the journal Nature Biomedical Engineering reported.

A model created by the Wyss team called the Lung Airway Chip contains two channels. One is filled with air and the other contains fluids that mimic human vascular cells and blood flow. Researchers said that a model about the same size as a Memory Stick grows airway cell types and develops characteristics similar to those of the human lung.

Rather than infecting the lung airway chip with the live SARS-CoV-2 virus, it is a dangerous proposal. Peplomers have the ability to bind to the ACE2 receptor in human lung cells. ” Description Co-authors Haiqing Bai, Ph.D., and Wyss postdoctoral fellows said in a statement.

Interestingly, lung models revealed that the two antimalarial drugs that caused the enthusiasm early in the pandemic, hydroxychloroquine and chloroquine, did not prevent the COVID-19 virus from entering the lungs. However, amodiaquine did so, as did the breast cancer drug toremifene and the fertility drug clomiphene. However, the researchers reported that amodiaquine was the most potent of the three and reduced chip infection by 60%.

Relation: Pfizer’s Vizimpro is one of three FDA-approved drugs that fight COVID-19 in lung cells: Report

The second respiratory model, created by researchers at Harvard University Brigham and Women’s Hospital, was designed to mimic the alveolar tissue below the human lung. The 3D model was able to grow airway cells and simulate human respiration. report It is published in the journal Proceedings of the National Academy of Sciences.

The Brigham and Women’s team plans to use this model to study how the COVID-19 drug affects cells in the lower lung. Researchers also believe that it will help study how new SARS-CoV-2 mutants cross the lungs and interact with drug treatment. Lung-on-chip may also advance research into other lung diseases, including lung cancer, they said.

“For COVID-19, there was very little timeline to develop a treatment. In the future, with these models at hand, treatments could be used in urgent situations with limited clinical trials. Easy to use for research and testing. ” Said Co-authors Y. Shrike Zhang, Ph.D. Associates Brigam and Women’s bioengineers in a statement.

For Wyss researchers, we worked with scientists at Mount Sinai School of Medicine to test amodiaquine against hydroxychloroquine in an animal model of COVID-19. In addition to reducing the viral load by 70%, they reported that amodiaquine had a 90% chance of preventing the transmission of the virus. The drug is currently being tested in patients with COVID-19 in Africa.


What Are The Main Benefits Of Comparing Car Insurance Quotes Online

LOS ANGELES, CA / ACCESSWIRE / June 24, 2020, / Compare-autoinsurance.Org has launched a new blog post that presents the main benefits of comparing multiple car insurance quotes. For more info and free online quotes, please visit https://compare-autoinsurance.Org/the-advantages-of-comparing-prices-with-car-insurance-quotes-online/ The modern society has numerous technological advantages. One important advantage is the speed at which information is sent and received. With the help of the internet, the shopping habits of many persons have drastically changed. The car insurance industry hasn't remained untouched by these changes. On the internet, drivers can compare insurance prices and find out which sellers have the best offers. View photos The advantages of comparing online car insurance quotes are the following: Online quotes can be obtained from anywhere and at any time. Unlike physical insurance agencies, websites don't have a specific schedule and they are available at any time. Drivers that have busy working schedules, can compare quotes from anywhere and at any time, even at midnight. Multiple choices. Almost all insurance providers, no matter if they are well-known brands or just local insurers, have an online presence. Online quotes will allow policyholders the chance to discover multiple insurance companies and check their prices. Drivers are no longer required to get quotes from just a few known insurance companies. Also, local and regional insurers can provide lower insurance rates for the same services. Accurate insurance estimates. Online quotes can only be accurate if the customers provide accurate and real info about their car models and driving history. Lying about past driving incidents can make the price estimates to be lower, but when dealing with an insurance company lying to them is useless. Usually, insurance companies will do research about a potential customer before granting him coverage. Online quotes can be sorted easily. Although drivers are recommended to not choose a policy just based on its price, drivers can easily sort quotes by insurance price. Using brokerage websites will allow drivers to get quotes from multiple insurers, thus making the comparison faster and easier. For additional info, money-saving tips, and free car insurance quotes, visit https://compare-autoinsurance.Org/ Compare-autoinsurance.Org is an online provider of life, home, health, and auto insurance quotes. This website is unique because it does not simply stick to one kind of insurance provider, but brings the clients the best deals from many different online insurance carriers. In this way, clients have access to offers from multiple carriers all in one place: this website. On this site, customers have access to quotes for insurance plans from various agencies, such as local or nationwide agencies, brand names insurance companies, etc. "Online quotes can easily help drivers obtain better car insurance deals. All they have to do is to complete an online form with accurate and real info, then compare prices", said Russell Rabichev, Marketing Director of Internet Marketing Company. CONTACT: Company Name: Internet Marketing CompanyPerson for contact Name: Gurgu CPhone Number: (818) 359-3898Email: [email protected]: https://compare-autoinsurance.Org/ SOURCE: Compare-autoinsurance.Org View source version on accesswire.Com:https://www.Accesswire.Com/595055/What-Are-The-Main-Benefits-Of-Comparing-Car-Insurance-Quotes-Online View photos

Pictures Credit


to request, modification Contact us at Here or [email protected]