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In a US study, SARS-CoV-2 reinfection was milder than primary infection

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Disclosure: Cresi reports that he is an AstraZeneca consultant. All other authors have not reported relevant financial disclosures.


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Reinfection with SARS-CoV-2 was rare and milder than primary infection, Clinical infections..

“Reinfection The possibilities remain Survivor of the first SARS-CoV-2 infection [the] The clinical picture is consistent with SARS-CoV-2 infection. “ Adnan I. Cresi MDA professor of clinical neurology at the University of Missouri told Healio.

COVID-19 reinfection
Source: Adnan Q, et al. Clin Infect Dis.. 2021; doi: 10.1093 / cid / ciab345.

“Therefore, the face mask, social distance and vaccination policies also apply to survivors of the first SARS-CoV-2 infection,” said Qureshi. “The results also indirectly suggest that vaccination may not provide complete immunity over the long term. You may need regular boosters.. “

Qureshi et al. Analyzed data from 9,119 patients with SARS-CoV-2 at 62 US healthcare facilities between December 1, 2019 and November 13, 2020. 90 days after the initial infection disappeared — related factors and mortality.

Adnan I. Cresi

The results showed that reinfection occurred in 0.7% of patients (95% CI, 0.15% -0.9%) with an average gap of 116 ± 21 days between positive tests. They found that asthma (OR = 1.9; 95% CI, 1.1-3.2) and nicotine addiction or tobacco use (OR = 2.7; 95% CI, 1.6-4.5) were associated with reinfection. ..

Two deaths were associated with reinfection, but reinfection had a significantly lower incidence of heart failure, pneumonia, and acute kidney injury compared to primary infection.

According to Cresi, the reinfection rates observed in this study are similar to those observed in the UK, Denmark, and Qatar studies, but vaccination, COVID-19 protocol, variant prevalence, and population Regional differences such as density mean “very important”. Get data from each region. “

Cresi also said that one of the limitations of this study was that reinfections were only counted if they occurred at least 90 days after the primary infection, which did not consider cases of previous reinfections. He said there was a possibility.

“It remains unclear whether some individuals are immunocompromised or whether new variants of SARS-CoV-2 can evade immunity to previous mutants,” said Qureshi. “In addition, unlike other viral infections, immunity after the initial SARS-CoV-2 infection can decline very rapidly.”

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