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Why Some Patients Are Covid Positive After Recovery, Health News, ET HealthWorld

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New York: Some viruses RNA New studies have been found that can be reverse transcribed and inserted into the human genome.This may explain why some people who have already recovered from Covid-19 sometimes mysteriously test positive. PCR Test after a few weeks or months.

Whitehead Institute of Biomedical Research and Massachusetts Institute of Technology (((WhenIn the United States, we have shown that the gene sequence of the RNA virus SARS-CoV-2 may be integrated into the host cell’s genome through a process called reverse transcription. You can then “read” these sections of the genome into RNA. This can be detected by PCR tests. The results are the journal Proceedings of the National Academy of Sciences..

SARS-CoV-2 is not the only virus that integrates into the human genome. About 8% of our DNA is made up of the remains of ancient viruses. Some viruses, called retroviruses, rely on integration into human DNA to replicate themselves.

“SARS-CoV-2 is not a retrovirus, which means it does not require reverse transcription for replication,” said Liguo Zhang, a postdoctoral fellow at Whitehead Institute.

“But nonretroviral RNA viral sequences have been detected in the genomes of many vertebrate species, including humans,” Zhang added.

With this in mind, the team analyzed public datasets of RNA transcripts from different types of samples, including Covid-19 patient samples, and could this viral integration occur with the new coronavirus? I tested it.

They were able to calculate the percentage of genes transcribed in the cells of these patients, including viral sequences that may be derived from the integrated viral copy.

The proportions vary from sample to sample, but it seems that a relatively large portion of some viral transcripts were transcribed from the viral genetic material integrated into the genome.

In the case of SARS-CoV-2, the frequency of human integration is still unknown. “The percentage of cells that integrate can be very small,” said Rudolf Jaenisch, a professor of biology at MIT.

“But, rarely, more than 140 million people are already infected, right?” Jaenisch said.

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