Disclosure: Wang reports that he is the co-inventor of the patent PCT / US2019 / 029937, a disposable reagent scaffold for biochemical process integration related to this study. See the survey for relevant financial disclosures of all other authors.
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New portable and quick test to detect Neisseria gonorrheaLess than 15 minutes — faster than standard treatment tests, which can take hours or even days.
Dr. Jeff Wang, A professor at the Johns Hopkins Whiting School of Engineering said the development of easy-to-use, fast, accurate, and low-cost STI tests is a “key factor” in the fight. STI’s “crisis”.
“Ability to respond quickly Identify N. Gonorrhea Characterize Antimicrobial susceptibility profile It has promising implications for promoting antimicrobial stewardship to reduce the selective pressure of antimicrobial resistance, “Wang told Healio.
“Ciprofloxacin is no longer recommended for the treatment of gonorrhea in the United States, but up to 80% of gonorrhea infections are still sensitive to ciprofloxacin,” Wang said. “The use of our platform’s Point of Care test to quickly identify susceptible infections is cheaper compared to the current first-line recommended dual therapies for injectable ceftriaxone and oral azithromycin. Open the opportunity to provide access to oral ciprofloxacin treatment. “
Wang et al. Developed a magnetohydrodynamic purification on the cartridge and a PCR test to detect it. N. gonorrhOSheeAnalyze resistance to ciprofloxacin. This test was used in penile swab samples from 66 patients in Baltimore and 151 patients in Kampala, Uganda. A compact tool performed DNA extraction, PCR, analyzed the results, and relayed the data to the patient via a telephone application.
The overall sensitivity of the test was 97.7% (95% CI, 94.7% -100%) and its specificity was 97.6% (95% CI, 94.1% -100%). Gonorrhea.. The test results were also 100% consistent with the ciprofloxacin resistant culture results.
“Practical advances in magnetohydrodynamic cartridge technology will revolutionize STI treatment and provide rapid gold standard infectious disease diagnosis in a scalable and accessible format that can streamline the use and management of antibiotics. It shows great potential, “says Wang.
Wang also said the material cost for the test cartridge was about $ 2.
“Delivery of our devices to low-rescue clinics requires regulatory approval and cooperation with industrial partners for manufacturing and distribution,” Wang said. “We are working towards this goal by forming a college spin-off and we plan to deliver the product within a couple of years.”
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