Health
Cystic Fibrosis Treatment Joint Splisense Raises $ 28.5 Million
Israeli biopharmacy cystic fibrosis treatment developer Splisense Today, it announced that it has completed a $ 28.5 million Series B funding round with investments from Orbimed, Israel Biotech Fund, Biotel Limited, Integra Holdings and the Cystic Fibrosis Foundation.
Based in Jerusalem, the company is developing treatments that alter the mRNA for cystic fibrosis (CF) and other hereditary lung diseases. SpliSense’s technology is based on the work of Professor Batsheva Kerem, a geneticist at the University of Hebrew, who was part of a research team that identified and cloned the CFTR gene.The technology was licensed from Yissum Technology Transfer Company, University of Jerusalem Hebrew..
The latest funding round will be used to advance the company’s pipeline, including the company’s leading antisense oligonucleotide (ASO) product, SPL84-23. SPL84-23 is designed to treat 3849 + 10kb C-> T CFTR mutations and has been shown to be able to fully restore cystic fibrosis transmembrane conductance regulator (CFTR) channel function in patient-derived cell cultures. I am. The company plans to begin Phase 1 / 2a trials in 2022.
Dr. Gili Hart, CEO of SpliSense, said: Available treatments focus on treating the symptoms of the disease, such as channel function and protein modulators, antibiotics to treat lung infections, mucilage thinning drugs, but treat the root cause of the disease. It’s not a thing. This provides CF patients with the hope of restoring proper lung function for the first time. We look forward to using this funding and the support of the Cystic Fibrosis Foundation to advance the pipeline for the benefit of CF patients. “
Dr. Nissim Darvish, Chairman of Splisense, said: We are looking forward to expanding into the pipeline clinic and expanding to additional indications. “
Israeli Business News, Published by Gloves- en.globes.co.il -May 13, 2021
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