Health
Immunodeficient patients show strong T cell activity against SARS-CoV-2
A recent study conducted by researchers at the National Hospital for Children in Washington, DC found that antibody-deficient adult and pediatric patients exhibited strong T-cell and humoral immune activity against. SARS-CoV-2 Structural protein.
The results of the study are Journal of Clinical Immunology..
“If the T cell response to SARS-CoV-2 is actually defensive, it may suggest that adoptive T cell immunotherapy may benefit patients with more severe immunodeficiency.” The technology for immunotherapy at Children’s National said. “Through the Phase I T-cell immunotherapy protocol under development, we plan to investigate whether coronavirus-specific T cells are defensive after bone marrow transplantation and in other immunodeficient populations.”
The team of researchers took blood samples from five patients with mild cases of COVID-19 due to antibody deficiency and one asymptomatic. Four of the participants were family members, and the study contrasted with fathers and accidental adults.
The results of this study showed that participants with antibody deficiency, including congenital immune disorders and general variable immunodeficiency, can initiate an immune response to the virus.
Researchers believe that the data suggest that people with antibody deficiency can respond to COVID-19 vaccination, but further studies show how much immunity is protected and how long it lasts. You need to judge.
“This was a small group of patients, but the high rate of response suggests that many antibody-deficient patients are more likely to initiate an immune response to SARS-CoV-2.” Keller said. “To find out if other patients with primary immunodeficiency develop immunity after COVID-19 infection, additional research is needed and a large scale organized by collaborators at the Garvan Institute in Sydney. There is a possibility that it will be answered by international cooperation. “
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