Connect with us


Studies have found that baby aspirin is sufficient to protect the heart




However, low doses were better adherent, so starting with “baby aspirin” may be the best choice for most patients, said Schuyler Jones, MD, an assistant professor of medicine at the Duke Clinical Institute (DCRI). It was. Lead author of a study called ADAPTABLE.Results at the same time New England Journal of Medicine..1

Many praised the practical design of this test, but it had one major drawback. Doctors couldn’t stop changing the patient’s dose, and many did. resulting in, journal We asked about the reliability of the findings and whether investigators need to run a pilot to clarify this issue.2

However, Jones welcomed the arrival of a direct comparison. “There wasn’t really a clear answer as to the most effective and safe dose of aspirin for these patients. Instead, there were contradictory findings that 81 mg may reduce the risk of bleeding. There are some studies that suggest, but higher doses may provide more effective prevention of heart attacks and strokes, “he said in a statement. “In these early studies, we primarily investigated aspirin (81 or 325 mg daily) compared to placebo.”

The study design combined classic clinical trial elements with electronic health records and billing data, including both commercial payer and CMS data. A secure website where patients can participate by mail, email, or phone and follow up every 3-6 months for a little over 2 years (26.2 months) from April 2016 to June 2019. I registered from. Established atherosclerotic cardiovascular disease and one other risk factor. The median age was 67 years. Most patients were white, 9% black, 3% Hispanic, and 1% Asian. The patient group was balanced at the beginning of the study, with 7540 taking 81 mg and 7536 taking a daily dose of 325 mg.

However, of the 96% who were taking aspirin before the study, 85% were taking baby aspirin. Also, during the study, dose switching was randomized to a daily dose of 325 mg compared to a dose of 81 mg (only 7.1% switching) (41.6% of this group had at least one dose). Was much more common among).

“We made every effort to maintain the study dose, but nevertheless people felt very strongly about it, so dose switching happened so often, especially in the 325 mg group. The different effects of the two doses on the two doses are less clear, “Jones said, noting that many patients in each group stayed at the doses assigned for more than a year. The investigator will perform additional analysis to learn why patients switch doses.

If the patient is taking 325 mg of aspirin and is well tolerated, it may be okay to continue, but if aspirin is restarted or started for the first time, it will probably start at a lower dose. need to do it.

Colin Baigent of Oxford University wasn’t very convinced. “Because switching is unlikely to be random, the bias resulting from this degree of crossover can mask the true difference in efficacy and / or safety, and is not significantly different. We can’t even conclude that, which means that the effects of the doses are comparable between the two dose groups, “he writes. journal.

The results are as follows.

  • Hazard ratio (HR) 1.02 (0.91- 1.14), P = 0.75.
  • The primary safety endpoint for this study was hospitalization for bleeding requiring blood transfusions. This is a rare event, with 53 participants taking a dose of 81 mg (0.63%) and a dose of 325 mg (0.60%) for HR (95% CI) = 1.18 (0.79 -1.77). It occurred only in 44 participants who took it.
  • Results were consistent regardless of age, race / ethnicity, gender, previous use of double antiplatelet therapy, or whether the patient had diabetes or chronic kidney disease.
  • During the study, 11% of the 325 mg group stopped taking aspirin, compared to 7% of the 81 mg group.

ADAPTABLE is the first clinical trial using PCORnet, the National Patient-Centered Clinical Research Network, a partnership of clinical research networks funded by the Patient-Centered Outcomes Institute (PCORI) that funded the study.


1. Jones WS, Mulder H, Wruck LM, etc. of the ADAPTABLE team. Comparison of the effectiveness of desired medications in cardiovascular disease. N Engl M Med.. Published May 15, 2021.

2. Baigent C. Practical testing-requires an adaptable design. N Engl J Med.. Published May 15, 2021. DOI: 10.1056 / NEJMe2106430


What Are The Main Benefits Of Comparing Car Insurance Quotes Online

LOS ANGELES, CA / ACCESSWIRE / June 24, 2020, / Compare-autoinsurance.Org has launched a new blog post that presents the main benefits of comparing multiple car insurance quotes. For more info and free online quotes, please visit https://compare-autoinsurance.Org/the-advantages-of-comparing-prices-with-car-insurance-quotes-online/ The modern society has numerous technological advantages. One important advantage is the speed at which information is sent and received. With the help of the internet, the shopping habits of many persons have drastically changed. The car insurance industry hasn't remained untouched by these changes. On the internet, drivers can compare insurance prices and find out which sellers have the best offers. View photos The advantages of comparing online car insurance quotes are the following: Online quotes can be obtained from anywhere and at any time. Unlike physical insurance agencies, websites don't have a specific schedule and they are available at any time. Drivers that have busy working schedules, can compare quotes from anywhere and at any time, even at midnight. Multiple choices. Almost all insurance providers, no matter if they are well-known brands or just local insurers, have an online presence. Online quotes will allow policyholders the chance to discover multiple insurance companies and check their prices. Drivers are no longer required to get quotes from just a few known insurance companies. Also, local and regional insurers can provide lower insurance rates for the same services. Accurate insurance estimates. Online quotes can only be accurate if the customers provide accurate and real info about their car models and driving history. Lying about past driving incidents can make the price estimates to be lower, but when dealing with an insurance company lying to them is useless. Usually, insurance companies will do research about a potential customer before granting him coverage. Online quotes can be sorted easily. Although drivers are recommended to not choose a policy just based on its price, drivers can easily sort quotes by insurance price. Using brokerage websites will allow drivers to get quotes from multiple insurers, thus making the comparison faster and easier. For additional info, money-saving tips, and free car insurance quotes, visit https://compare-autoinsurance.Org/ Compare-autoinsurance.Org is an online provider of life, home, health, and auto insurance quotes. This website is unique because it does not simply stick to one kind of insurance provider, but brings the clients the best deals from many different online insurance carriers. In this way, clients have access to offers from multiple carriers all in one place: this website. On this site, customers have access to quotes for insurance plans from various agencies, such as local or nationwide agencies, brand names insurance companies, etc. "Online quotes can easily help drivers obtain better car insurance deals. All they have to do is to complete an online form with accurate and real info, then compare prices", said Russell Rabichev, Marketing Director of Internet Marketing Company. CONTACT: Company Name: Internet Marketing CompanyPerson for contact Name: Gurgu CPhone Number: (818) 359-3898Email: [email protected]: https://compare-autoinsurance.Org/ SOURCE: Compare-autoinsurance.Org View source version on accesswire.Com:https://www.Accesswire.Com/595055/What-Are-The-Main-Benefits-Of-Comparing-Car-Insurance-Quotes-Online View photos

Pictures Credit


to request, modification Contact us at Here or [email protected]