New Antiviral Drug Developed with 99.9% Efficacy Against COVID-19 | Weather Channel-Weather Channel Articles

An international team of scientists from Australia and the United States has developed an direct-acting antiviral therapy that could reduce viral load by 99.9% and provide a new treatment for COVID-19.

Traditional antiviral drugs such as Tamiflu, zanamivir, and remdesivir alleviate symptoms and help people recover early.

A new antiviral approach uses gene silencing RNA technology called siRNA (small interfering RNA) to directly attack the viral genome and block viral replication. This approach uses lipid nanoparticles designed by Griffith University and Hope City to deliver siRNA to the lungs, a key site of infection.

“Treatment with virus-specific siRNA reduces viral load by 99.9%. These stealth nanoparticles can be delivered to a wide range of lung cells and silence the viral genes,” said Menzies Health Institute Queensland (MHIQ). Co-principal Investigator Professor Nigel McMillan said. ) At Griffith University.

When tested in mice infected with SARS-Cov-2, therapeutic treatment improved the chances of survival.Notably, treatment survivors failed to detect the virus in the lungs, according to a study published in the journal. Molecular therapy, report.

“This treatment is the original SARS virus (SARS-CoV-1), all beta coronaviruses such as SARS-CoV-2, and the viral genome,” said Professor and Deputy Director of the Gene Therapy Center in Hope. One Kevin Morris added.

In addition, researchers have shown that nanoparticles are stable at 4 ° C for 12 months and at room temperature for more than a month. This means that this agent can be used in a low resource configuration to treat infected patients.

Furthermore, this result suggests that siRNA-nanoparticle formulations can be developed as a treatment for COVID-19 patients and that they can be used for future coronavirus infections by directly targeting the viral genome.

“These nanoparticles are scalable and relatively cost-effective for mass production,” Morris said.

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The above article is published from a wire source with minimal changes to headlines and text.

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