Health

This test uses only a small blood sample to detect proteins secreted by M. tuberculosis. This causes tuberculosis infection-ScienceDaily

Researchers at Tulane University School of Medicine have developed a sensitive blood test that can detect traces of bacteria that cause tuberculosis (TB) in babies a year before the onset of a fatal disease. BMC medicine..

This test uses only a small blood sample to detect M. tuberculosis proteins secreted by M. tuberculosis. All forms of tuberculosis can be screened and the patient’s response to treatment can be quickly assessed, said Dr. Tony Fu, principal research author and Chairman of the President of Biotechnology Innovation at Tulane University.

“This is a breakthrough for infants with tuberculosis because there is no screening technique of this kind to catch the early infections of the youngest group most likely to be undiagnosed,” Hu said. .. “I hope we can take this approach quickly and reach these children as soon as possible.”

Every year, nearly 1 million children develop tuberculosis and 205,000 die from tuberculosis-related causes. Over 80% of deaths from childhood tuberculosis occur in people under the age of five. Most of these deaths occur because children with tuberculosis, especially babies, usually have no symptoms specific to tuberculosis and therefore have not been diagnosed with the disease. These children also have difficulty producing respiratory samples used to detect tuberculosis with the best tuberculosis tests currently in use.

Even when these samples are available from children, they often have a much lower bacterial content than adult samples, which tends to make the diagnosis less effective, Hu said. However, his test uses a small amount of blood samples that can be easily taken from children of all ages to detect a specific protein (CFP-10) secreted by bacteria to maintain an infection that develops into tuberculosis. I will. Because this protein is present in the blood at very low levels, Hu’s assay uses antibodies specific for this protein to concentrate it from other proteins in the blood and is sensitive using a mass spectrometer. And it detects accurately.

Hu and his team used this test to collect from 284 and 235 non-virus-infected children who participated in a large clinical trial conducted between 2004 and 2008. The stored blood samples were screened. Hu’s group found that the current Gold Standard tuberculosis test identified children diagnosed with tuberculosis with 100% accuracy. The assay also detected 83.7% of tuberculosis cases missed by these tests, but was subsequently diagnosed by a standard checklist using a set of other information collected by each child’s doctor (unconfirmed). Tuberculosis cases). Hu’s test also detected CFP-10 in 77% of blood samples collected 24 weeks before the child was otherwise diagnosed with tuberculosis, indicating a high likelihood of early TB diagnosis. It was. Biomarkers in some positive cases can be detected 60 weeks before tuberculosis is confirmed.

Researchers are working on developing inexpensive, portable devices for reading tests so that resources commonly found in tuberculosis-endemic areas can be used more easily in confined environments.

This study was funded by the National Institute of Allergy and Infectious Diseases, the Eunice Kennedy Schreiber National Institute of Pediatric Health and Human Development, and the US Department of Defense.

Story source:

material Provided by Tulane University.. Original written by Carolyn Scofield. Note: The content can be edited in style and length.

What Are The Main Benefits Of Comparing Car Insurance Quotes Online

LOS ANGELES, CA / ACCESSWIRE / June 24, 2020, / Compare-autoinsurance.Org has launched a new blog post that presents the main benefits of comparing multiple car insurance quotes. For more info and free online quotes, please visit https://compare-autoinsurance.Org/the-advantages-of-comparing-prices-with-car-insurance-quotes-online/ The modern society has numerous technological advantages. One important advantage is the speed at which information is sent and received. With the help of the internet, the shopping habits of many persons have drastically changed. The car insurance industry hasn't remained untouched by these changes. On the internet, drivers can compare insurance prices and find out which sellers have the best offers. View photos The advantages of comparing online car insurance quotes are the following: Online quotes can be obtained from anywhere and at any time. Unlike physical insurance agencies, websites don't have a specific schedule and they are available at any time. Drivers that have busy working schedules, can compare quotes from anywhere and at any time, even at midnight. Multiple choices. Almost all insurance providers, no matter if they are well-known brands or just local insurers, have an online presence. Online quotes will allow policyholders the chance to discover multiple insurance companies and check their prices. Drivers are no longer required to get quotes from just a few known insurance companies. Also, local and regional insurers can provide lower insurance rates for the same services. Accurate insurance estimates. Online quotes can only be accurate if the customers provide accurate and real info about their car models and driving history. Lying about past driving incidents can make the price estimates to be lower, but when dealing with an insurance company lying to them is useless. Usually, insurance companies will do research about a potential customer before granting him coverage. Online quotes can be sorted easily. Although drivers are recommended to not choose a policy just based on its price, drivers can easily sort quotes by insurance price. Using brokerage websites will allow drivers to get quotes from multiple insurers, thus making the comparison faster and easier. For additional info, money-saving tips, and free car insurance quotes, visit https://compare-autoinsurance.Org/ Compare-autoinsurance.Org is an online provider of life, home, health, and auto insurance quotes. This website is unique because it does not simply stick to one kind of insurance provider, but brings the clients the best deals from many different online insurance carriers. In this way, clients have access to offers from multiple carriers all in one place: this website. On this site, customers have access to quotes for insurance plans from various agencies, such as local or nationwide agencies, brand names insurance companies, etc. "Online quotes can easily help drivers obtain better car insurance deals. All they have to do is to complete an online form with accurate and real info, then compare prices", said Russell Rabichev, Marketing Director of Internet Marketing Company. CONTACT: Company Name: Internet Marketing CompanyPerson for contact Name: Gurgu CPhone Number: (818) 359-3898Email: [email protected]: https://compare-autoinsurance.Org/ SOURCE: Compare-autoinsurance.Org View source version on accesswire.Com:https://www.Accesswire.Com/595055/What-Are-The-Main-Benefits-Of-Comparing-Car-Insurance-Quotes-Online View photos

Pictures Credit