Connect with us


HCQ, Immune System, and COVID-19: Unanswered Questions




Researchers say that using hydroxychloroquine (HCQ) to treat COVID-19 is surrounded by more hype than the data and little is known about the effects of the virus on the immune system. I am.

“[T]He has a known strong immunomodulatory effect [HCQ and its close cousin chloroquine] Supporting their use in the treatment of autoimmune diseases, providing the original rationale component for their use in COVID-19 patients, and indeed their usefulness in the context of the treatment of this respiratory viral infection There is a possibility of damaging the property. Mark Poznansky, PhD, and colleagues at the Massachusetts General Hospital in Boston To FASEB journal.

Poznansky wants him to look into the literature because his own clinical experience is that there are many COVID-19 patients with hydroxychloroquine when he was undergoing clinical services and they are “not doing very well”. I said that is one of the reasons.

“It wasn’t a” wow, this drug keeps the patient away from the ICU “type of feeling,” he said. MedPage today Separately.

The widespread use of the immunosuppressant hydroxychloroquine made Poznansky unusual and pointed out that clinicians should carefully consider this particular drug in the context of acute viral infections.

“There’s a lot of literature on the fact that hydroxychloroquine is quite immunosuppressive. Even an article in the Journal of Immunology said it dramatically reduced immune function. And I said,” hey Wait, we’re using this in patients with acute viral infections, “Poznansky noted.

As the group’s paper points out, he was not the only one observing this phenomenon. “The first case report from China led to the first widespread adoption of HCQ, and less so. [chloroquine] For many hospitalized COVID-19 patients worldwide. “

In fact, Michael Liu, AB of Oxford University in the UK, combined Google search such as “buy” and “order” and retail sites such as Amazon and Walmart with hydroxychloroquine and chloroquine from February 1st to March 29th. The letter JAMA Internal MedicineThey said that the eccentric businessman Elon Musk approved the use of the drug on March 16, a publicly announced speech by President Trump on March 19, and a chloroquine-related addiction on March 22. We have identified important dates, such as the first report.

The researchers found that the biggest spike occurred after a prominent public talked very much about the drug: a search for hydroxychloroquine purchases was 1,389% higher than the previous six weeks, and a search for chloroquine was 442. % High, searches remained high even after news coverage Drug-related addiction.

“The findings on the clinical efficacy of chloroquine and hydroxychloroquine were not conclusive at the time these drugs were advertised,” Liu and colleagues said.

Poznansky and colleagues pointed to the lack of clinical evidence for this drug, for example, the “widespread secondary effects” of hydroxychloroquine, or “strong immune regulation,” which, although effective in regulating the immune system, It is not clear how these effects of affect people with acute COVID-19. ”

“We don’t fully understand the immune response to COVID-19, and it’s only a few months,” Poznansky said. “We don’t fully understand the immune response to HIV, which has been around for decades. We apply immunomodulators to diseases where the role of the immune system in fighting the virus is unknown. doing.”

In addition, the key immune function that you say is important for fighting the virus seems to be suppressed by hydroxychloroquine: “Whether hydroxychloroquine downregulates the COVID-19 immune response. I haven’t tested it directly. It’s a necessary gap and is bridged here. “

Clinical trials addressing the use of hydroxychloroquine hope to provide some of these answers. Poznansky said that research needs to determine the effect of hydroxychloroquine on the clinical progression of the disease, and the researchers “have a complete understanding of what needs to be measured in the context of hydroxychloroquine associated with immune function. No. “

“Does it suppress cytokine storms? Do patients with hydroxychloroquine have lower levels of cytokines than patients without hydroxychloroquine?” Poznansky asked. “This kind of thinking needs to be applied to the use of COVID-19 immunomodulators.”

Last updated: April 30, 2020

  • Author['full_name']

    Molly walker Molly Walker is an associate editor responsible for MedPage Today’s infectious diseases. She has a passion for evidence, data and public health. Follow


The authors do not disclose conflicts of interest.


What Are The Main Benefits Of Comparing Car Insurance Quotes Online

LOS ANGELES, CA / ACCESSWIRE / June 24, 2020, / Compare-autoinsurance.Org has launched a new blog post that presents the main benefits of comparing multiple car insurance quotes. For more info and free online quotes, please visit https://compare-autoinsurance.Org/the-advantages-of-comparing-prices-with-car-insurance-quotes-online/ The modern society has numerous technological advantages. One important advantage is the speed at which information is sent and received. With the help of the internet, the shopping habits of many persons have drastically changed. The car insurance industry hasn't remained untouched by these changes. On the internet, drivers can compare insurance prices and find out which sellers have the best offers. View photos The advantages of comparing online car insurance quotes are the following: Online quotes can be obtained from anywhere and at any time. Unlike physical insurance agencies, websites don't have a specific schedule and they are available at any time. Drivers that have busy working schedules, can compare quotes from anywhere and at any time, even at midnight. Multiple choices. Almost all insurance providers, no matter if they are well-known brands or just local insurers, have an online presence. Online quotes will allow policyholders the chance to discover multiple insurance companies and check their prices. Drivers are no longer required to get quotes from just a few known insurance companies. Also, local and regional insurers can provide lower insurance rates for the same services. Accurate insurance estimates. Online quotes can only be accurate if the customers provide accurate and real info about their car models and driving history. Lying about past driving incidents can make the price estimates to be lower, but when dealing with an insurance company lying to them is useless. Usually, insurance companies will do research about a potential customer before granting him coverage. Online quotes can be sorted easily. Although drivers are recommended to not choose a policy just based on its price, drivers can easily sort quotes by insurance price. Using brokerage websites will allow drivers to get quotes from multiple insurers, thus making the comparison faster and easier. For additional info, money-saving tips, and free car insurance quotes, visit https://compare-autoinsurance.Org/ Compare-autoinsurance.Org is an online provider of life, home, health, and auto insurance quotes. This website is unique because it does not simply stick to one kind of insurance provider, but brings the clients the best deals from many different online insurance carriers. In this way, clients have access to offers from multiple carriers all in one place: this website. On this site, customers have access to quotes for insurance plans from various agencies, such as local or nationwide agencies, brand names insurance companies, etc. "Online quotes can easily help drivers obtain better car insurance deals. All they have to do is to complete an online form with accurate and real info, then compare prices", said Russell Rabichev, Marketing Director of Internet Marketing Company. CONTACT: Company Name: Internet Marketing CompanyPerson for contact Name: Gurgu CPhone Number: (818) 359-3898Email: [email protected]: https://compare-autoinsurance.Org/ SOURCE: Compare-autoinsurance.Org View source version on accesswire.Com:https://www.Accesswire.Com/595055/What-Are-The-Main-Benefits-Of-Comparing-Car-Insurance-Quotes-Online View photos

Pictures Credit


to request, modification Contact us at Here or [email protected]