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Better COVID-19 vaccine may not be spike-centric

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Aiming at the spikes helps us to be clear.The vaccines we have built against the coronavirus continue to be a surprisingly effective shield primarily against disease. Because Protein is a very good educational tool for the immune system ready for a duel. Spikes, which help unlock the virus and invade human cells, are one of the most prominent and dangerous features of pathogens and one of the first to be discovered by immune cells and molecules during patrol. ..

Vaccines that teach the immune system to recognize spikes are probably vaccines that teach the immune system to work effectively. high speed-Probably fast enough to welay the invading virus before it invades the cell. This process, called neutralization, is performed by certain types of antibodies, Worshiped position in the field of vaccine science, David Martinez, a vaccine expert at the University of North Carolina at Chapel Hill, told me.The vaccinated person Sufficient neutralizing antibodyAs the theory goes, they need very little else to stop the disease.And the spike protein Leading antibody bait.. “Spike stays here — it’s a must,” Sumita Ayer, an immunologist at the University of California, Davis, told me.

However, while antibodies focus on the target with laser-sharp precision, they are easily confused by changes. Even the slightest changes in the structure of the spikes can cause molecules to aggregate on the surface of the virus and make it difficult to heal it. Each viral antibody evasion mutant has a slightly readjusted version of the spike, Currently appearing in several countries, South Africa, Brazil, India, and the United States. Will continue more reliably.

None of our current vaccines have been completely disabled by a variant of the coronavirus. modern And Pfizer We plan to create additional shots that include a fine-tuned, variant-aware version of Spike. The problem is that strategies like these can quickly lock us into a terribly mismatched fencing match. Microbes mutate much faster than humans invent vaccines, and each new thrust has only time to parry in return. When the spike works alone, it creates an obvious immunological loophole that the virus can slip through.

There is another solution. The immune system can be targeted by feeding more masses of the virus. Some vaccines, which contain whole coronavirus particles, are chemically neutralized and do not cause a true infection. Already approved,including Couple made by Chinese company Sinopharm.. However, all viral vaccines can be painful to manufacture and have had various consequences in the past.

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