A new study aimed at determining the prevalence of sucrase isomaltase deficiency in adults Diarrhea-Major Irritable Bowel Syndrome (IBS-D) Functional diarrhea due to limited data on symptomatic adult SIDs.
A researcher led by Samuel Chay MPH, Department of Gastroenterology, Michigan Internal Medicine, identified the SID in nearly 1 in 10 patients with IBS-D or functional diarrhea.
The study was virtually published 2021 Gastrointestinal Disease Week (DDW) Virtual Meeting..
An ongoing study recruited adult patients aged 18 years or older who met the Roman IV criteria for IBS-D or functional diarrhea and would undergo esophagogastric duodenal endoscopy.
Researchers excluded patients from the study because of pregnancy, other IBS subtypes, severe comorbidities with GI, or a history of previous GI surgery.
Eligible patients in this study completed the IBS Symptom Severity Scale (IBS-SSS) by undergoing upper endoscopy with a small bowel biopsy collected from the distal duodenum of the ampulla.
The biopsy specimen was then subjected to a disaccharidase assay (DA) for SI activity (normal sucrase: ≥28.0 µM / min / g, normal maltase: ≥120.8 µM / min / g).
A total of 58 patients were enrolled in the study, with an average age of 42.6 years, 74% female and 93% Caucasian.
Of the patient population, 67% had IBS-D and 33% had functional diarrhea. Mean IBS-SSS was 232 ± 17, which included moderate and severe abdominal pain and abdominal distension scores.
The researchers found that not all patients in the study were satisfied with their bowel habits and felt that their symptoms were frequent interference.
Of the 58 patients, 5 were positive for SID via DA, with an average IBS-SSS score of 218 ± 4, suffering from moderate severe abdominal pain and abdominal distension score.
Five SID-positive patients were equally dissatisfied with bowel habits, but their symptoms felt more disruptive to their daily lives compared to the entire study population.
The team reported that 4 of 5 SID patients reported lifelong problems with gastrointestinal pain such as abdominal discomfort and loose stools, and 4 of 5 patients had diarrhea within 10 years of participating in the study. I discovered that I had reported the onset of.
All five SID patients were treated from a low FODMAP diet to antidiarrheal medication.
Researchers said two of the five SID patients were found to have carcinoid tumors after participating in the study.
Researchers have concluded that patients with SID present with lifelong symptoms and tend to have serious disruptions to their daily lives.
“These results require validation in a larger patient sample, but that SID may be an important and overlooked cause of symptoms in U.S. patients diagnosed with IBS-D or functional diarrhea. It suggests, “the researchers write.
the study, “Prevalence of sucrase-isomartese deficiency in adults with irritable bowel syndrome and diarrhea and functional diarrhea: interim analysis from a prospective US study, ”Was published online by DDW.
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