Health
The DNACOVID-19 vaccine provided with the help of electrical pulses shows early prospects
Effective mRNA vaccines from Moderna and BioNTech have proven value against COVID-19, but shots that use DNA to encode vaccine antigens are not yet on the market.
Researchers at the National Institutes of Health in Taiwan have now developed a DNACOVID-19 vaccine that is delivered to cells with the help of electrical pulses.Candidates elicited high levels of antibody response in animals and protected hamsters from disease, according to results published in the journal. PLOS neglected tropical disease..
The team argues that a DNA vaccine called pSARS2-S may offer a more stable option for COVID compared to mRNA shots that require ultra-low temperatures for transport and storage.
Encoding vaccine antigens using DNA is a logical approach. However, DNA vaccines have so far only been approved for veterinary use, as the immune response in humans is often not sufficient to provide clinically meaningful protection. This is partly due to the inefficient delivery of DNA to cells for antigen expression.
As a candidate, the Taiwanese team relied on a technique called electroporation. Electroporation uses electrical pulses to open temporary pores in the cell membrane and allow the vaccine’s DNA material to pass through. In the current study in animals, immunization was followed by treatment with an electroporator device.
Relation: Preparation of next-generation COVID-19 vaccine and treatment
Like many other existing COVID vaccines, the team designed a shot that encodes the SARS-CoV-2 coronavirus peplomer behind the disease.
In both mice and hamsters, the vaccine elicited a strong antibody response to the spike protein. Antibodies peaked 8 weeks after immunization, but levels remained high at 20 weeks.
The researchers further evaluated the efficacy of the vaccine by administering the SARS-CoV-2 virus to hamsters at week 7 after the animals were immunized twice at 3-week intervals. Animals that took dummy shots lost about 11% of their body weight after 6 days as a sign of COVID disease, but DNA-vaccinated animals were protected from weight loss and had significantly reduced lung viral RNA. did.
Relation: Inovio’s funding of the COVID-19 vaccine was frustrated as the United States expressed gratitude,
Compared to other vaccine platforms, few research groups have chosen the DNA pathway to develop COVID vaccines. Inovio, one of the race’s leaders, recently withdrew funding from the U.S. federal government for Phase 3 trials of its DNA candidate, INO-4800, because of the rapid rollout of existing FDA-approved shots. Retreated to. Shots are also based on electroporation for delivery, but concerns are targeting the Cellectra 2000 device used by Inovio.
The Taiwanese team suggests that the DNA vaccine may be a useful approach for controlling COVID-19, given the long-term antibody response observed in the candidates. “The DNA vaccine is an ideal vaccine platform with several advantages, including ease of design and manufacture, stability at different temperatures, and low manufacturing costs,” scientists said in a study. I will.
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