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The pill has been shown to be effective against certain breast cancers that are difficult to treat.National

 


Early-reported findings show that pills repel certain early-stage breast cancers that are difficult to treat after initial treatment. Because they are very promising.

The findings were published Thursday by the American Society of Clinical Oncology prior to the Annual Meeting and published in the New England Journal of Medicine.

This tablet, called Lynparza, has been found to help breast cancer patients with adverse mutations live longer without getting sick after treating their cancer with standard surgery and chemotherapy.

Studies have been conducted in patients who have mutations in the genes known as BRCA1 and BRCA2 and are prone to breast cancer if they do not function properly, but do not have the genetic defect targeted by the drug Herceptin.

Most of the patients who participated in the study also had tumors that were not energized by the hormones estrogen and progesterone. Cancers that are not fueled by these two hormones or the Herceptin target gene are called “triple negatives.” They are especially difficult to treat.

A new study tested olaparib in 1,836 women and men with early-stage disease who received drugs or placebo pills for one year after surgery and chemotherapy. Approximately 82% of the patients who participated in the study had triple-negative breast cancer.

The independent monitor recommended releasing the results after confirming the obvious benefits of Lynparza. Three years later, 86% of patients who took it survived without recurrence of the cancer, compared to 77% of the placebo group.

The results suggest that more patients should undergo BRCA mutation testing of tumors to guide treatment decisions, said Dr. Lori Pierce, chairman of ASCO, a cancer radiation expert at the University of Michigan. Said.

Serious side effects were not common with drugs. Other side effects include anemia, fatigue, and abnormal blood cell counts.

Limpaza, marketed by AstraZeneca and Merck, is already being marketed in the United States and elsewhere for the treatment of widespread breast cancer and for certain cancers of the ovaries, prostate and pancreas. Patients pay about $ 14,000 a month, depending on their income, insurance, and other factors.

This study was supported by AstraZeneca and the National Cancer Institute.

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The Associated Press’s Department of Health Sciences is supported by the Department of Science Education at the Howard Hughes Medical Institute. AP is solely responsible for all content.

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