Health
Combination Targeted Therapy Provides Sustained Relief in CLL Patients
Killer T cells surround cancer cells. Credit: NIH
Researchers at the University of Texas MD Anderson Cancer Center have found that the combination of ibrutinib and venetoclax provides persistent relief for patients with a newly diagnosed chronic lymphocytic leukemia (CLL). Results of a single-center phase II study are available today JAMA Oncology It provides the longest follow-up data for patients treated with this medication.
Leading researchers included Dr. Nitin Jain, MD, an associate professor of leukemia, and Dr. William Wierda, MD, a professor of leukemia. And Dr. Varsha Gandhi are heads of the Department of Experimental Therapeutics.
MD Anderson researchers previously reported the results of this study, with ibrutinib and venetoclax at high risk and Elderly patient I’m sick. This report provides additional two years of tracking data and statistics. Bone marrow Undetectable, measurable residual lesion (U-MRD) after treatment. Overall, the 3-year progression-free survival rate was 93% and the 3-year overall survival rate was 96%. The response rate for the high-risk patient subgroup was similar.
“CLL is the most common leukemia in the United States and was initially treated with chemoimmunotherapy,” said Jain. “These long-term results show that two years of oral targeted therapy can achieve lasting effects. Illness remission For CLL patients. “
The researchers followed 80 untreated patients with a median age of 65 years, 30% of whom were 70 years or older. The median follow-up period for all 80 patients was 38.5 months. The study participants were 94% Caucasian, 4% others, 1% Native American or Alaska Natives, and 1% unknown.
The U-MRD response was improved with continuous ibrutinib plus venetoclax. After 12 cycles of combination therapy, 56% of patients achieved bone marrow U-MRD and after 24 cycles of combination therapy, 66% of patients achieved bone marrow U-MRD remission. A total of 75% of patients achieved bone marrow U-MRD remission at any time during the study.
“MRD is one of the most important prognostic markers at the end of leukemia treatment,” Jain said. “The majority of patients achieved remission of bone marrow MRD, and none of the patients in the study had advanced CLL disease.”
The research team continues to monitor patient MRD every 6 months for further correlation studies. The treatment was well tolerated, the toxicity profiles of both drugs were consistent with other studies, and no additional toxicity was observed with the combination.
Several ongoing studies are investigating BTK inhibitors in combination with venetoclax, including the CAPTIVATE trial, which was recently reported at the American Society of Clinical Oncology (ASCO). Annual meeting, UK FLAIR, CLL17, and CLL GLOW trials will report Phase III results at the European Society of Hematology (EHA) virtual conference.Data from these trial And others clarify the duration and role of this treatment plan.
“I think this will be one of the few standard treatments available to patients with CLL,” says Jain. “Each of these approaches has its strengths and weaknesses, and doctors need to decide which option is best for their patients.”
JAMA Oncology (2021). jamanetwork.com/journals/jamao… /jamaoncol.2021.1649
Provided by
University of Texas MD Anderson Cancer Center
Quote: CLL (June 10, 2021) combination therapy obtained from https://medicalxpress.com/news/2021-06-combination-therapy-durable-remission-patients.html on June 10, 2021 Provides lasting remission
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