Health
Survey of Inhaled Nitrous Oxide for Treatment-Resistant Depression-Consumer Health News
Thursday, June 10, 2021 (HealthDay News) –For treatment-resistant major depression (TRMD), 25% nitrous oxide is as effective as 50% nitrous oxide, with a higher incidence of side effects. It will be lower.June 9 issue Science translational medicine..
Noting that 50% nitrous oxide improved the depressive symptoms of TRMD, Dr. Peter Nagele of the University of Chicago investigated the effectiveness of 25% nitrous oxide in TRMD. Twenty-four patients with severe TRMD were randomly assigned to inhale 50% nitrous oxide, 25% nitrous oxide, or placebo for 1 hour.
Researchers found that nitrous oxide significantly improved depressive symptoms compared to placebo (P = 0.01), but there was no difference between 25% and 50% nitrous oxide (P = 0.58). I found that. Estimated differences in the Hamilton Depression Rating Scale are -0.75 (P = 0.73), -1.41 (P = 0.52), -4.35 (P = 0.05), and -5.19 points (P = 0.02) at 2 and 24 hours. did. Between 25% nitrous oxide and placebo, 1 week and 2 weeks, respectively. For 50% nitrous oxide and placebo, the corresponding estimated differences are -0.87 (P = 0.69), -1.93 (P = 0.37), -2.44 (P = 0.25), and -7.00 points (P = 0.001). did. Low doses significantly reduced adverse events (P <0.001).
“The reduction in side effects was unexpected and fairly dramatic, but even more exciting, the effect lasted for a full two weeks with a single dose,” Nagele said in a statement. “This has never been shown. It’s a very cool discovery.”
Several authors have revealed financial ties to the pharmaceutical industry. One author has previously applied for protection of intellectual property rights related to the use of nitrous oxide in major depression.
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What Are The Main Benefits Of Comparing Car Insurance Quotes Online
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