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Wessex FM-News-Coronavirus: Scientists welcome “breakthrough” discovery of antibodies to prevent infection

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9:29 AM, May 4, 2020.

(Updated at 10:59 am on May 4, 2020)

Scientists have discovered antibodies that prevent coronaviruses from infecting human cells.

Based on SARS research Coronavirus, Utrect University, The Netherlands, Erasmus Medical Center and Harbor BioMed (HBM) scientists identified potential methods of neutralization COVID-19 (New Coronavirus Infection) (# If there is no character limit, add parentheses when first appearing.

A peer-reviewed study published Monday in Nature Communications found that antibodies that prevent the SARS virus from infecting human cells could also block the new coronavirus from infecting human cells. Did.

The researchers tested a collection of antibodies against cultured human cells and found one that binds to specific moieties present on both SARS and the virus that causes COVID-19.

The discovery provides the first step towards the development of fully human antibodies to treat or prevent disease, infecting more than 3.5 million people and killing more than 247,000 people worldwide.

Neutralizing antibodies “may alter the path of infection in infected hosts, support viral clearance, and protect non-infected individuals exposed to the virus,” the co-author of the study said. Said one Dr. Berend-Jan Bosch.

Frank Grosveld, another co-author of the study, provided the finding “a strong foundation for additional research to characterize this antibody and initiate development as a potential treatment for COVID-19.” I said.

“The antibodies used in this study are” fully human, “allowing them to develop more quickly and reduce the potential for immune-related side effects,” he added.

Fully human antibodies differ from traditional therapeutic antibodies. Conventional therapeutic antibodies can infect humans after they were first developed in other species and then “humanized.”

It was developed using Harbor BioMed’s H2L2 transgenic mouse technology-mice genetically engineered to contain human genes, allowing researchers to test them in living people. To enable the development of “human” antibodies.

“This is a groundbreaking study,” said Dr. Jingsong Wang, CEO of HBM.

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