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Third shots can help boost the Covid Defense of transplant patients


Vaccine booster shots may help strengthen the defense of some organ transplant recipients against Covid-19. When the pandemic restriction ends, groups that fear suppression of the immune system can be vulnerable.

According to a small study reported in the Annals of Internal Medicine on Monday, one-third of organ recipients who did not have antibodies after the second dose developed antibodies after the third dose. The researchers also found that participants with slightly elevated antibodies after the double-dose regimen had higher levels after taking additional shots.

The results are thought-provoking Johns Hopkins University researcher.But they were eagerly waiting Porting community As the pandemic weakens, we are about to return to normal activity. Since 2017, about 160,000 transplants have been made in the United States.

“It shows us that the immune system of immunosuppressed patients can be activated,” he said. Dolly Segef, One of the university researchers and a professor of surgery and epidemiology.

Early research by Johns Hopkins researchers Indicated Transplant recipients who must suppress the immune system with drugs so that the body does not reject the donated organs are less likely to develop antibodies after two doses of the messenger RNA vaccine. Pfizer Japan Inc And its partners BioNTech SE And Moderna Inc.

Results of those surveys Spurred Some patients go to pharmacies or clinics themselves to get booster shots. Johns Hopkins researchers then recorded antibody levels in 30 of these patients to create up-to-date data.

Read more: Transplants force patients to vaccinate to defeat Covid

Segev said on the phone that further research is needed to determine the timing and conditions of the third dose and what options are available for patients who do not respond after the third dose. ..

Segev says his team is working with the US Food and Drug Administration, National Institute of Health Attempts to begin clinical trials in the next few months when researchers can give patients a third dose in a controlled setting.

Side effects

The FDA states that it needs data to evaluate alternative dosing regimens. Centers for Disease Control and Prevention At this time, we do not recommend taking multiple vaccine series. For transplant patients, taking the new vaccine risks inducing the immune system in ways that can lead to organ rejection, Segev said.

In the Johns Hopkins study, researchers did not observe anaphylactic reactions or neurological complications. One heart transplant recipient experienced rejection that was found to have antibodies to the donated organs one week after the third dose, but recovered and was the rejection related to the vaccine? I don’t know.

According to Segev, a small number of patients have received or are considering a fourth dose, and researchers are studying them as well. However, he said, if someone does not respond after the third dose, it is unlikely that they will respond after the additional dose.

Patients who do not respond after the third dose may need to take other steps, such as adjusting immunosuppressive drugs, but may be at risk for transplant patients due to the risk of organ rejection. ..

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